南方汉族人群慢性荨麻疹与幽门螺杆菌感染的关系研究

目的探讨幽门螺杆菌感染(HP)与南方汉族人群慢性荨麻疹(CU)发病的相关性及临床意义。方法采用~(13)C呼气试验检测60例南方汉族CU患者和50例健康对照者,将伴发HP感染的47例CU患者,用随机数字表法分为A、B两组,A组患者采用CU标准治疗联合抗HP标准三联疗法治疗;B组患者采用抗过敏治疗,2个月为1个疗程,比较每组患者经治疗后的病情转归状况。结果 CU患者中感染HP的共有47例,而健康人组中有30例,两组患者的HP感染率比较,差异有统计学意义(P<0.05)。经过2个月的治疗,A组的治疗总有效率为86.95%,完全缓解率为58.3%,与B组比较有明显的优势,两组比较差异有统计学意义(P<0.05)。结论南方汉族人群患CU与HP感染有一定的关联性,用联合抗HP的方法对HP(+)的CU患者进行治疗,可在短期提高CU的治疗效果并提高其远期缓解率。

Relationship between chronic urticaria and helicobacter pylori infection in southern Han population

Objective To investigate the relationship between helicobacter pylori （ HP ） infection and chronic urticaria （ CU ） in southern Han population and its clinical significance. Methods HP infection was detected in 60 CU patients and 50 healthy con- trois by using 13 C breath test. The HP （ ＋ ） patients with CU （ n = 47） were divided into two groups according to random number table, i.e. Group A which received standard CU treatment plus anti-HP standard triple therapy and Group B which received CU standard treatment alone. The curative results of urticaria were compared between the two groups after two months＇ treatment. Results The positive rate of the CU patients （ 47 cases） was significantly higher than that of the heahhy controls （ 30 cases） （ P 〈 0.05）. The curative rate and the complete remission rate in Group A were 86.95% and 58.3% , significantly higher than that in Group B （ P 〈 0.05 ）. Conclusion There is a correlation between HP infection and CU in southern Han population. The combined therapy including anti-HP can improve the short-term curative effect and long-term remission rate in CU patients.