生脉注射液在高龄感染性休克患者中的应用价值及对ET-1、NO表达的影响

目的探讨生脉注射液在高龄感染性休克患者中的应用价值及对ET-1、NO表达的影响。方法高龄感染性休克患者46例,分为对照组(22例)和试验组(24例),对照组给予常规综合性治疗,试验组在对照组治疗基础上,加用生脉注射液,观察患者血压、心率、休克改善状况及血清C反应蛋白(CRP)、降钙素原(PCT)、内皮素1(ET-1)、一氧化氮(NO)的水平。结果试验组总有效率87.5%,明显高于对照组的59.1%(P<0.05)。治疗1周后,试验组CRP、PCT、ET-1、NO水平明显低于对照组,差异有统计学意义(P<0.01),ET-1/NO比值明显高于对照组,差异有统计学意义(P<0.05)。结论生脉注射液治疗高龄感染性休克患者疗效显著,能降低患者CRP、PCT水平,其机制可能与抑制ET-1和NO过度生成,纠正ET-1/NO紊乱有关。

Application of Shengmai injection to treatment for elderly patients with septic shock and its influence on ET-1 and NO

Objective To study the clinical application of Shengmai injection to the treatment for elderly patients with septic shock and its influence on endothelin-1 （ ET-1 ） and nitrogen oxide （NO）. Methods A total of 46 elderly patients with septic shock were divided into control group （n = 22 ） and trial group （n = 24 ）. The trial group was treated with Shengmai injection in addition to the conventional treatment administered in the control group. Serial measurements of blood pressure, heart rate, improvement in shock, serum C-reactive protein （CRP） , PCT, ET-1 and NO were made before and one week after treatment. Results The total effective rate of the trial group was 87.5% , significantly higher than that （59. 1% ） of the control group（ P 〈 0.05 ）. After one week＇ s treatment,the serum CRP and PCT levels in the trial group were declined significantly when compared with that in the con- trol group（P 〈0.01 ）. The ET-1 and NO levels in the trial group were significantly lower than that in the control group （P 〈0.01 ） , and ET-1/NO ratio was significantly higher in the trial group than in the control group （ P 〈 0.05 ）. Conclusion Shengmai injec- tion is therapeutically effective on elderly patients with septic shock, for it helps to reduce CRP and PCT levels, which may be related to the inhibition of over-production of ET-1 and NO and to the correction of ET-1/NO disorder.