正常成人多层螺旋CT灌注成像的脑血流动力学研究

目的:探讨多层螺旋CT灌注成像结合去卷积算法在成人脑血流动力学中的应用。方法:选择13例正常成年人行常规头颅CT平扫后,再行CT灌注成像检查。在常规轴面CT扫描后选取基底节及其相邻层面,经肘静脉团注对比剂,同时开始连续50s的四层动态扫描,重建的198幅动态图像使用CT脑灌注软件包进行处理,获得灌注图像,测量所选脑内感兴趣区的血流量、血容量及平均通过时间,并对其进行定量分析。结果:多层螺旋CT灌注成像显示正常成年人脑灰质灌注高于脑白质,脑灰质的平均血流量、平均血容量、平均通过时间分别为(54.7±11.3)ml/(min·100g)、(2.9±0.5)ml/100g、(3.4±0.6)s;脑白质的平均血流量、平均血容量、平均通过时间分别为(27.9±6.9)ml/(min·100g)、(2.4±0.4)ml/100g、(3.9±0.5)s。结论:多排螺旋CT灌注成像结合去卷积算法较其他模式更具有重要的实用价值及优势,同时多层螺旋CT灌注成像结合去卷积技术为测量正常人脑血流动力学指标提供了一种新的影像学方法。

The Cerebral Hemodynamics Study by Using Multislice CT Perfusion Imaging in Normal Adult

Objective To explore the application of multislice CT perfusion imaging in normal adult cerebral hemodynamics.Methods Routine CT was performed in 13 normal adults,then multislice CT perfusion imaging study was made by selecting the basal ganglia slice and its adjacent slice.The contrast material was bolus injected through antecubital vein ,while four layers of dynamic scans were performed for 50 seconds.These slice dynamic images were processed with the CT perfusion software package.Cerebral blood flow (CBF),cerebral blood volume (CBV),and mean transit time (MTT) were measured within the specific regions of interest (ROI) of the brain,and quantitative analysis was performed.Results A gradient of perfusion between gray matter and white matter was showed on multislice CT perfusion imaging in normal adults.CBF,CBV,and MTT were (54.7±11.3)ml/(min·100 g)、(2.9±0.5)ml/100 g、(3.4±0.6)s,respectively in the gray matter and (27.9±6.9)ml/(min·100 g)、(2.4±0.4)ml/100 g、(3.9±0.5)s respectively in the white matter.Conclusion Multislice CT perfusion scanning with deconvolution analysis is a method that has important practical advantages over previously available methods and provided a new imaging method for measuring the cerebral hemodynamics.