| 盐酸多西环素精制结晶工艺的改进 |
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| 引用本文： | 刘益华.盐酸多西环素精制结晶工艺的改进[J].齐鲁药事,2004,23(2):54-55. |
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| 作者姓名： | 刘益华 |
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| 作者单位： | 江苏省黄海药业有限公司,大丰,224100 |
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| 摘 要： | 目的 考察多西环素精制结晶工艺条件。方法 用氯化氢 -乙醇代替CP盐酸进行精制结晶。结果 使用氯化氢 -乙醇代替CP盐酸可得到合格的盐酸多西环素结晶。结论 多西环素结晶时以氯化氢 -乙醇代替CP盐酸,质量易于控制,特别对产品的黑杂点控制有一定作用
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| 关 键 词： | 多西环素 氯化氢-乙醇 CP盐酸 结晶 工艺改进 |
| 文章编号： | 1672-7738(2004)02-0054-02 |
Improvement of crystallization process of Doxycycline Hydrochloride |
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| Liu Yi-hua.Improvement of crystallization process of Doxycycline Hydrochloride[J].qilu pharmaceutical affairs,2004,23(2):54-55. |
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| Authors: | Liu Yi-hua |
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| Abstract: | Objective Crystallization process of Doxycycline Hydrochloride was studied.Methods HCl-CH 3CH 2OH was used in crystallization instead of Hydrochloric acid.Results Qualified Doxycycline Hydrochloride was obtained using HCI-CH 3CH 2OH instead of Hydrochloric acid.Conclusion Using HCl-CH 3CH 2OH instead of Hydrochloric acid can easily improve the quality of Doxycycline Hydrochloride during crystallization,especially to control black mixtures. |
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| Keywords: | Doxycycline Hydrochlorine-Ethanol Hydrochloric acid crystallization improvement of process |
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