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Transglutaminase in cell proliferation and transformation |
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| Authors: | Salvatore Metafora Gianfranco Peluso Gianpietro Ravagnan Magda Marchese Michele di Pietro Aldo Mancini Nicola Panza Antonio Fusco Raffaele Porta |
| Affiliation: | 1. CNR Institute of Protein Biochemistry and Enzymology, Via Toiano 6, 80072, Arco Felice, Naples 2. CNR Institute of Experimental Medicine, Viale C. Marx 15, 00156, Rome 3. National Cancer Institute, Naples 4. Oncology Department, Cardarelli Hospital, Naples 5. Department of Biochemistry and Biophysics, University of Naples, Naples, Italy |
| Abstract: | Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation. A decrease in TGase activity in neoplastically transformed seminal vesicle epithelial cells with respect to their normal parent counterpart was also observed. Our data support the notion of a possible implication of TGase in cell proliferation and transformation. |
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