| 血管性痴呆与事件相关电位 |
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| 引用本文： | 卢家红,陈兴时,吕传真. 血管性痴呆与事件相关电位[J]. 中国临床神经科学, 2000, 8(2): 96-98 |
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| 作者姓名： | 卢家红 陈兴时 吕传真 |
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| 作者单位： | 1. 上海医科大学附属华山医院神经内科,200040
2. 上海市精神卫生中心电生理室,200030 |
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| 摘 要： | 目的探讨血管性痴呆的事件相关电位(P300)特点，及P300用于鉴别血管性痴呆和阿尔茨海默病的可能性。方法选用听觉oddball诱发范式对24例血管性痴呆(VD)、25例阿尔茨海默病(AD)和22例正常老年人(NC)进行P300测试。结果VD的P300特点为靶P3潜伏期延长，靶N2潜伏期延长并与认知障碍程度密切相关。VD与AD相比，AD的靶P2及靶P3波幅明显下降。结论靶N2潜伏期是VD的P300研究中一项重要指标，靶P2、P3波幅在VD与AD的鉴别诊断中有一定意义。
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| 关 键 词： | 事件相关电位 P300 血管性痴呆 阿尔茨海默病 |
| 修稿时间： | 2000-01-03 |
Vascular Dementia and Event Related Potential |
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| LU Jian-Hong,CHEN Xin-Shi,LU Chuan-Zhen. Vascular Dementia and Event Related Potential[J]. Chinese Journal of Clinical Neurosciences, 2000, 8(2): 96-98 |
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| Authors: | LU Jian-Hong CHEN Xin-Shi LU Chuan-Zhen |
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| Affiliation: | LU Jian-Hong(Department of Neurology, Huashan Hospital, Shanghai Medical University,Shanghai 200040)CHEN Xin-Shi(Department of Electrophysiology,Shanghai Mental Health Cencer)LU Chuan-Zhen(Department of Neurology, Huashan Hospital, Shanghai Medical University,Shanghai 200040) |
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| Abstract: | Aim: To study the characteristic of event related potential (P300) in vascular dementia and to evaluate the role of P300 in the differential diagnosis of vascular dementia and Alzheimer's disease. Methods: Odd ball auditory evoked model was used to test the P300 of 24 patients with vascular dementia(VD), 25 patients with Alzheimer's dementia (AD) and 22 normal controls (NC). Results: The characteristic of P300 in VD shows the target P3 potential was prolonged. the target N2 potential was also prolonged and correlated with the extent of dementia. The target P2,P3 amplitudes in AD was greatly de- creased in compare with that in VD. Conclusion: The target N2 potential is a very important item in P300 of VD: the tests of the target P2,P3 amplitudes make sense in the differential diagnosis of VD and AD. |
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| Keywords: | event related potential P300 vascular dementia Alzheimer's disease |
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