A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus) |
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| Authors: | T Bengone-Ndong S Kiki Mvouaka Y Kane W A Loudy-Moukédé L J Panguy M Alvinerie |
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| Institution: | (1) Institut de Recherches Agronomiques et Forestières (IRAF), Centre National de la Recherche Scientifique et Technologique (CENAREST), BP 2246, Libreville, Gabon;(2) Ecole Normale Supérieure (ENS), BP 17009, Libreville, Gabon;(3) Ecole Inter-Etats des Sciences et Médecine Vétérinaires (EISMV), BP 5077, Dakar Fann, Sénégal;(4) Laboratoire de Pharmacologie–Toxicologie, INRA, 180, chemin de Tournefeuille, BP 3, 31931 Toulouse Cedex 09, France |
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| Abstract: | The plasma kinetics of doramectin and moxidectin were evaluated in zebu Gobra under field conditions after subcutaneous administration
of 0.2 mg kg−1 of commercially available formulations for cattle. The results indicate that the absorption of moxidectin from the site of
injection was significantly faster (absorption half-life t
1/2ab] = 0.7 day) than that of doramectin (t
1/2ab = 3.1 days). Moxidectin peak plasma concentration (C
max) was reached significantly earlier (t
max = 0.4 day) compared with that of doramectin (t
max = 5.3 days). No differences in C
max values were observed; the area under the concentration–time curve was higher for doramectin (475 ng day ml−1) compared with moxidectin (198 ng day ml−1), while the mean residence time was longer for moxidectin (13.4 days) compared with doramectin (9.4 days). These results
obtained give interesting information on doramectin and moxidectin pharmacokinetics in zebu Gobra, which show a similar pharmacokinetic
profile as in other cattle. |
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