| 单药希罗达治疗晚期恶性肿瘤 |
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| 引用本文： | 林云笑,陈昌南,黄活勋.单药希罗达治疗晚期恶性肿瘤[J].赣南医学院学报,2008,28(4):580-581. |
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| 作者姓名： | 林云笑 陈昌南 黄活勋 |
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| 作者单位： | 广东省江门市新会区人民医院肿瘤科,广东,江门,529100 |
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| 摘 要： | 目的：探讨希罗达单药治疗晚期恶性肿瘤的近期疗效及不良反应。方法：43例晚期恶性肿瘤患者均给予希罗达口服，每日2次，餐后服用，2500mg／m^2·d，连续服用14d后停药7d，治疗周期为21d，至少治疗2个周期。结果：43例均可评价，完全缓解（CR）1例，部分缓解（PR）11例，病情稳定（SD）20例，疾病进展（PD）11例，总有效率27．9％，临床获益率74．4％。不良反应：手足综合征（HFS）22例，色素沉着21例，恶心10例，呕吐8例，厌食12例，腹泻10例，白细胞下降12例，血小板下降4例，大多数为Ⅰ-Ⅱ度，2例Ⅲ度HFS，1例Ⅲ度色素沉着。结论：希罗达治疗晚期恶性肿瘤疗效肯定，用药方便，耐受性好，不良反应轻。
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| 关 键 词： | 恶性肿瘤 晚期 希罗达 |
Efficacy of single-agent Xeloda in treatment of patients with advanced cancer |
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| LIN Yun-xiao,CHEN Chang-nan,HUANG Huo-xun.Efficacy of single-agent Xeloda in treatment of patients with advanced cancer[J].Journal of Gannan Medical College,2008,28(4):580-581. |
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| Authors: | LIN Yun-xiao CHEN Chang-nan HUANG Huo-xun |
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| Institution: | Xinhui People's Hospital;Jiangmen;Guangdong 529100 |
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| Abstract: | Objective:To evaluate the efficacy and safety of single-agent Xeloda in patients with advanced cancer.Methods:43 patients were treated with Xeloda,2500mg/m2/d,twice daily,on days 1~14 every 21 days.At least 2 cycles were administered.Results:The overall response rate was 27.9%,the benefit rates were 74.4%,with 1 CR,11 PR,20 SD and 11 PD.In terms of adverse reaction,foot and hand syndrome could be seen in 22 patients,skin pigmentation in 21 patients.Nausea,vomiting,anorexia and diarrhea were observed in 10,8... |
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| Keywords: | advanced cancer xeloda chemotherapy |
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