Immunogenicity, safety, and memory of different schedules of Neisseria meningitidis A/C-diphtheria toxoid conjugate vaccine in infants in Niger |
| |
Authors: | Chippaux J-P Garba A Ethevenaux C Campagne G de Chabalier F Djibo S Nicolas P Ali H Charrondière M Ryall R Bybel M Schuchat A |
| |
Affiliation: | CERMES, B.P. 10887, Niamey, Niger. chippaux@ird.sn |
| |
Abstract: | We studied one to four doses of meningococcal polysaccharides A and C conjugated to diphtheria toxoid (Men D) versus A/C polysaccharide (Men PS) vaccine in 618 infants in Niger. Men PS at 24 months permitted evaluating memory. Two Men D doses (at 3 and 9 months) induced higher serum bactericidal activity (SBA) than other regimens. SBA titers after Men PS at 24 months were higher in those given Men D in infancy versus Men PS. While responses were lower for serogroup C, hyporesponsiveness was not evident. Men D was well-tolerated. A single Men D dose in infancy appeared to induce memory. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|