Langzeitbeobachtung bei 15 Patienten mit differenziertem Schilddrüsenkarzinom und unklar erhöhten Plasmathyreoglobulinspiegeln (Tg) |
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Authors: | H -P Stumpf Prof Dr M Hüfner H -J Hermann B Kimmig |
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Institution: | (1) Medizinische Universitäts-Poliklinik, Germany;(2) Universitäts-Strahlenklinik Heidelberg, Germany |
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Abstract: | Summary The follow-up of 15 patients with differentiated cancer of the thyroid was analysed retrospectively. All patients had persistent or developed elevated thyroglobulin (Tg) plasma levels (>10 ng/ml) after total thyroidectomy and 131 I therapy. There was no evidence of thyroid remnants or metastases in the 131 I whole body scan, bone scan, chest X-ray or clinical investigation. Nine of 15 patients developed local or distant metastases during a follow-up period of 3–39 months (mean=18 months). Only one of seven recurrences tested were 131 I positive, Tg values of 9 from 12 patients showed no correlation to the Thyroid-stimulating hormone (TSH) level. It is concluded that: (1) this group of patients is at high risk of developing a recurrence (2) new methods have to be developed for the localization of 131 I negative but Tg positive metastases.Teile dieser Arbeit wurden beim 27. Symposium der Deutschen Gesellschaft für Endokrinologie 1983 in Frankfurt vorgetragen 19] |
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Keywords: | Plasma thyroglobulin Thyroid cancer |
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