| 耳蜗电刺激并脑源性神经营养因子联合应用对大鼠耳蜗病理及听觉生理的影响 |
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| 引用本文： | 蔡超,倪志立,张立松,房高丽,李永新. 耳蜗电刺激并脑源性神经营养因子联合应用对大鼠耳蜗病理及听觉生理的影响[J]. 中国耳鼻咽喉头颈外科, 2011, 0(8): 440-444 |
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| 作者姓名： | 蔡超 倪志立 张立松 房高丽 李永新 |
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| 作者单位： | 首都医科大学附属北京地坛医院耳鼻咽喉头颈外科;首都医科大学宣武医院耳鼻咽喉头颈外科;首都医科大学附属北京同仁医院耳鼻咽喉头颈外科耳鼻咽喉头颈科学教育部重点实验室(首都医科大学); |
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| 基金项目： | 国家自然科学基金项目(30572028); 北京市自然科学基金项目(7032008); 北京市科技新星计划(9558101300)联合资助 |
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| 摘 要： | 目的 探讨延迟给予慢性电刺激、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF),以及二者联合应用对药物致聋大鼠耳蜗病理及听觉生理影响.方法 药物致聋大鼠40只,随机平均分为人工外淋巴液组(artificial perilymph,AP)、BDNF组、电刺激(electr...
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| 关 键 词： | 大鼠 动物实验 听觉丧失,感音神经性 电刺激疗法 脑源性神经营养因子 电诱发听性脑干反应 螺旋神经节细胞 |
Delayed electrical stimulation and BDNF application following induced deafness in rats |
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| CAI Chao,NI Zhili,ZHANG Lisong,FANG Gaoli,LI Yongxin,Ministry of Education,.... Delayed electrical stimulation and BDNF application following induced deafness in rats[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2011, 0(8): 440-444 |
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| Authors: | CAI Chao NI Zhili ZHANG Lisong FANG Gaoli LI Yongxin Ministry of Education ... |
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| Affiliation: | CAI Chao1,NI Zhili2,ZHANG Lisong1,FANG Gaoli1,LI Yongxin3(1 Department of Otolaryngology Head and Neck Surgery,Ditan Hospital,Capital Medical University,Beijing,100015,China,2 Department of Otolaryngology Head and Neck Surgery,Xuanwu Hospital,100053,3 Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,100... |
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| Abstract: | OBJECTIVE To determine the infiuence of delayed intervention of combination of electrical stimulation(ES)and neurotrophin application on the survival of spiral ganglion cells(SGCs)body,peripheral process and the auditory sensitivity after induced deafness in rat.METHODS The left cochlea of profoundly deafened rats was implanted with an electrode and drug-delivery system 30 days after induced deafness.BDNF or artificial perilymph(AP)was delivered continuously for 28 days.ES induced neural activity was in two... |
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| Keywords: | Rats Animal Experimentation Hearing Loss Sensorineural Electric Stimulation Therapy Brain-Derived Neurotrophic Factor electrically evoked auditory brainstem response spiral ganglion cells |
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