| HPLC法测定醋酸泼尼松龙乳膏的含量 |
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| 引用本文： | 薛玉玲,薛玉榕. HPLC法测定醋酸泼尼松龙乳膏的含量[J]. 海峡药学, 2011, 0(8): 69-70 |
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| 作者姓名： | 薛玉玲 薛玉榕 |
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| 作者单位： | 1. 福建省妇幼保健院 福州350001
2. 福建省省立医院 福州350001 |
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| 摘 要： | 目的建立高效液相色谱法测定醋酸泼尼松龙乳膏中醋酸泼尼松龙含量的方法。方法采用Phenomenex Luna C18（250mmⅹ4.6mm,5μm）色谱柱,以乙腈-水（65∶35）为流动相,流速为1.0mL.min-1,检测波长为246nm。结果醋酸泼尼松龙在10.00~100.0μg.mL-1范围内浓度与峰面积呈良好的线性关系（r=0.9998）,平均回收率为99.7%,RSD为0.7%（n=9）。结论本方法简便、快速、结果准确,重现性好。
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| 关 键 词： | 含量测定 醋酸泼尼松龙乳膏 高效液相色谱法 |
Determination of prednisolone acetate in prednisolone acetate crean by HPLC |
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| XUE Yu-ling,XUE Yu-rong. Determination of prednisolone acetate in prednisolone acetate crean by HPLC[J]. Strait Pharmaceutical Journal, 2011, 0(8): 69-70 |
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| Authors: | XUE Yu-ling XUE Yu-rong |
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| Affiliation: | XUE Yu-ling1,XUE Yu-rong2(1.Health & care hospital for women and children of Fujian province Fuzhou 350001,China,2.Fujian shengli hospital Fuzhou 350001,China) |
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| Abstract: | OBJECTIVE To establish a method for determination content of prednisolone acetate in prednisolone acetate crean by HPLC.METHODS Phenomenex Luna C18(250mmⅹ4.6mm,5μm)column was used and acetonitrile-water(65∶35) was used as mobil phase,the flow rate was 1.0mL·min-1,the detecting wavelength was at 246nm.RESULTS There was a good linear relationship between the concentration of prednisolone acetate and peak area within a range of 10.00~100.0μg·mL-1(r=0.9998).The average recover was 99.7%,with RSD=0.67%(n=9).CONCLUSION The method is highly repeatable and accurate. |
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| Keywords: | Content Prednisolone acetate crean HPLC |
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