| 水飞蓟素平衡溶解度及表观油水分配系数的测定 |
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| 引用本文： | 何琳,龙晓英,丁沐淦,叶晓芬,梁静敏,顾嘉慧,李志棠,李国辉.水飞蓟素平衡溶解度及表观油水分配系数的测定[J].广东药学院学报,2011,27(5):445-449. |
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| 作者姓名： | 何琳 龙晓英 丁沐淦 叶晓芬 梁静敏 顾嘉慧 李志棠 李国辉 |
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| 作者单位： | 1. 广东药学院中药学院,广东广州,510006
2. 广东岭南职业技术学院,广东广州,510663 |
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| 基金项目： | 国家自然科学基金面上项目(30973953C1909) |
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| 摘 要： | 目的 考察水飞蓟素在37℃下,在不同pH磷酸盐缓冲溶液中的平衡溶解度和表观油水分配系数.方法 采用气浴恒温振荡器摇瓶法测定水飞蓟素的平衡溶解度及表观油水分配系数,紫外-可见分光光度法测定水飞蓟素在正辛醇-缓冲体系的质量浓度.结果 37℃时,水飞蓟素在pH 2.0、3.0、4.0、5.0、6.0、6.8、7.4、8.0、...
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| 关 键 词： | 水飞蓟素 平衡溶解度 表观油水分配系数 |
Determination of equilibrium solubility and apparent oil/water partition coefficient of silymarin |
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| HE Lin,LONG Xiao-ying,DING Mu-gan,YE Xiao-fen,LIANG Jing-min,GU Jia-hui,LI Zhi-tang,LI Guo-hui.Determination of equilibrium solubility and apparent oil/water partition coefficient of silymarin[J].Academic Journal of Guangdong College of Pharmacy,2011,27(5):445-449. |
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| Authors: | HE Lin LONG Xiao-ying DING Mu-gan YE Xiao-fen LIANG Jing-min GU Jia-hui LI Zhi-tang LI Guo-hui |
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| Institution: | HE Lin1,LONG Xiao-ying1,DING Mu-gan2,YE Xiao-fen1,LIANG Jing-min1,GU Jia-hui1,LI Zhi-tang1,LI Guo-hui1 (1.School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China,2.Guangdong Lingnan Institute of Technology,Guangzhou 510663,China) |
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| Abstract: | Objective To determine the equilibrium solubility and the apparent oil/water partition coefficient of silymarin in different pH phosphate buffer solutions in 37 ℃.Methods A shake flask-ultraviolet spectrophotometry method was applied to determine the equilibrium solubility and partition coefficient of silymarin.Concentrations of silymarin in n-octanol-buffer solutions of different pH were detected by UV.Results The equilibrium solubility of silymarin in different phosphate buffer solution of pH 2.0,3.0,4.0,5.0,6.0,6.8,7.4,8.0,9.0 were 0.673,0.681,0.776,0.848,0.937,1.218,1.486,1.504,1.691 mg·mL^-1,and the oil/water apparent partition coefficient of silymarin in different pH respectively were 57.12,10.83,15.56,7.39,10.19,3.82,2.75,1.79,0.84 in 37 ℃.Conclusion The equilibrium solubility and apparent oil/water partition coefficient were correlated to the pH of medium.With the increase of pH value,the equilibrium solubility rised,while the apparent oil/water partition coefficient decreased. |
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| Keywords: | silymarin equilibrium solubility apparent oil/water partition coefficient |
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