| 溴吡斯的明N-三甲基壳聚糖包衣脂质体的研制及其体外释药研究 |
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| 引用本文： | 樊军,何文. 溴吡斯的明N-三甲基壳聚糖包衣脂质体的研制及其体外释药研究[J]. 广东药学院学报, 2011, 27(5): 455-458. DOI: 10.3969/j.issn.1006-8783.2011.05.003 |
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| 作者姓名： | 樊军 何文 |
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| 作者单位： | 1. 武汉大学人民医院药学部,湖北武汉430060;武汉大学药学院,湖北武汉430072
2. 武汉大学人民医院药学部,湖北武汉,430060 |
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| 摘 要： | 目的 研制溴吡斯的明(PB)的阳离子脂质体,并对其体外释药进行考察.方法 采用逆向蒸发法制备PB脂质体(PB-L),以N-三甲基壳聚糖(TMC60)为包衣材料对其进行包衣,制备阳离子型PB-L,并用正交设计法对其处方进行优化；对溴吡斯的明脂质体包衣前后的形态、粒径、Zeta电位及体外释药特性进行考察.结果 最优处方为卵...
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| 关 键 词： | 溴吡斯的明 N-三甲基壳聚糖 阳离子脂质体 体外释药 |
Study on the preparation and in vitro release of pyridostigmine bromide liposomes coated by N-trimethyl chitosan |
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| FAN Jun,HE Wen. Study on the preparation and in vitro release of pyridostigmine bromide liposomes coated by N-trimethyl chitosan[J]. Academic Journal of Guangdong College of Pharmacy, 2011, 27(5): 455-458. DOI: 10.3969/j.issn.1006-8783.2011.05.003 |
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| Authors: | FAN Jun HE Wen |
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| Affiliation: | FAN Jun1,2,HE Wen1(1.Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China,2.College of Pharmacy,Wuhan University,Wuhan 430072,China) |
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| Abstract: | Objective To prepare cationic liposomes loaded pyridostigmine bromide(PB) and study their in vitro release.Methods The PB liposomes(PB-L) were prepared by reverse phase evaporation followed by N-trimethyl chitosan(TMC60) coating.Orthogonal design was used to optimize the TMC60-coated PB-L formulation.The morphology,size,Zeta potential and in vitro release property of the formulation were studied compared with the uncoated PB-L.Results The optimal technological conditions were as the follows: the ratio of le... |
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| Keywords: | pyridostigmine bromide N-trimethyl chitosan cationic liposomes in vitro release |
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