| 硫化氢对自发性高血压大鼠主动脉平滑肌细胞增生的影响 |
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| 引用本文： | 蒲红,焦昆立. 硫化氢对自发性高血压大鼠主动脉平滑肌细胞增生的影响[J]. 世界临床药物, 2011, 32(10) |
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| 作者姓名： | 蒲红 焦昆立 |
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| 作者单位： | 中国人民解放军第八五医院心内科,上海,200052 |
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| 摘 要： | 目的探讨硫化氢(H2S)对自发性高血压大鼠(SHR)主动脉平滑肌细胞(ASMC)增生的影响。方法体外培养SHR ASMC,将其分成对照组、10-5、10-4和l0-3 mol/L NaHS组,检测经H2S处理后ASMC细胞的增生指数和丝裂原活化蛋白激酶(MAPK)活性。结果与对照组相比,10-5、10-4和10-3 mol/L NaHS组增生指数显著降低(P<0.01),MAPK活性明显下降(P<0.05或P<0.01)。结论 H2S可抑制SHR ASMC增生和MAPK活性,推测可能通过MAPK信号途径介导。
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| 关 键 词： | 硫化氢(H2S) 自发性高血压大鼠 主动脉平滑肌细胞 丝裂原活化蛋白激酶 |
Effect of hydrogen sulfide on proliferation of cultured spontaneously hypertensive rat aortic smooth muscle cell |
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| PU Hong,JIAO Kun-li. Effect of hydrogen sulfide on proliferation of cultured spontaneously hypertensive rat aortic smooth muscle cell[J]. WORLD CLINICAL DRUGS, 2011, 32(10) |
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| Authors: | PU Hong JIAO Kun-li |
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| Affiliation: | PU Hong,JIAO Kun-li(Department of Cardiology,People's Liberation Army 85th Hospital,Shanghai 200052,China) |
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| Abstract: | Objective To investigate the effect of hydrogen sulfide(H2S) on proliferation of cultured spontaneously hypertensive rat(SHR)aortic smooth muscle cells(ASMCs).Methods Cultured ASMCs of SHRs were divided into the control group,10-5,10-4 and 10-3 mol/L NaHS groups.ASMCs proliferative index and mitogen-activated protein kinase(MAPK) activity were determined.Results Compared with the control group,ASMC proliferative index decreased significantly(P<0.01) and MAPK activity weakened(P<0.05 or P<0.01) in 10-5,10-4 ... |
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| Keywords: | hydrogen sulfide(H2S) spontaneously hypertensive rat aortic smooth muscle cell mitogen-activated protein kinase |
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