| α-细辛脑海藻酸钙微球的制备及体外释放药物考察 |
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| 引用本文： | 伍善广,裴世成,陈丽,冯艺萍. α-细辛脑海藻酸钙微球的制备及体外释放药物考察[J]. 海峡药学, 2011, 0(8): 29-31 |
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| 作者姓名： | 伍善广 裴世成 陈丽 冯艺萍 |
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| 作者单位： | 柳州医学高等专科学校 柳州 545006 |
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| 摘 要： | 目的研究α-细辛脑海藻酸钙微球的制备工艺,测定微球中α-细辛脑的体外释放度。方法采用乳化-内部凝胶化法制备海藻酸钙微球,正交试验设计优化制备工艺,分光光度法测定α-细辛脑的含量。结果最优工艺微球球形圆整,载药量为1.17%,包封率为2.40%,微球的平均粒径为17.97μm,大部分微球粒径分布在7~30μm（93.67%）,体外释放符合双相动力学方程Q/100=0.8276-0.0506exp（-1909t）-0.777exp（-0.4405t）。结论以海藻酸钠为载体、乳化-内部凝胶化法制备了海藻酸钙微球,获得微球制备工艺。
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| 关 键 词： | α-细辛脑 海藻酸钙微球 制备 体外释放 |
Preparation and in vitro release of asarone calcium alginate microspheres |
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| WU Shang-uang,PEI Shi-cheng,CHEN Li,FENG Yi-ping. Preparation and in vitro release of asarone calcium alginate microspheres[J]. Strait Pharmaceutical Journal, 2011, 0(8): 29-31 |
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| Authors: | WU Shang-uang PEI Shi-cheng CHEN Li FENG Yi-ping |
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| Affiliation: | WU Shan-guang,PEI Shi-cheng,CHEN Li,FENG Yi-ping(Liuzhou Medical College,Liuzhou 545006) |
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| Abstract: | OBJECTIVE To optimize the preparation process and study in vitro release of asarone calcium alginate microspheres.METHODS Asarone calcium alginate microspheres were prepared by emulsion-inner gelation methods.Preparation process was optimized by an orthogonal test.Content and amounts of accumulative release in vitro were analyzed by using ultraviolet spectrometry.RESULTS Asarone calcium alginate microspheres were regular in its morphology.The drug loading was 1.17%,the average encapsulation efficiency was 2... |
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| Keywords: | Asarone Calcium alginate microspheres Preparation In vitro release |
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