| 正交试验优选小儿退热栓的提取工艺研究 |
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| 引用本文： | 陈琳,许家鸾,王京霞. 正交试验优选小儿退热栓的提取工艺研究[J]. 海峡药学, 2011, 0(8): 32-34 |
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| 作者姓名： | 陈琳 许家鸾 王京霞 |
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| 作者单位： | 浙江省中医院 杭州 310053 |
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| 摘 要： | 目的对小儿退热栓的渗漉提取工艺进行优化。方法用乙醇作溶剂渗漉提取处方中大黄的活性成分,按正交表L9（34）安排试验,以大黄总蒽醌含量为指标,考察影响乙醇渗漉效率4个因素：浸泡时间、乙醇浓度、乙醇体积及渗漉流速。结果大黄总蒽醌醇渗漉提取的最佳工艺为：浸泡48h后用12倍量的70%乙醇以1.5mL.min-1的流速渗漉提取。结论本法能最大限度地提取处方中大黄的有效成分,可为小儿退热栓的工业化生产提供理论依据。
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| 关 键 词： | 小儿退热栓 正交试验 大黄总蒽醌 |
Optimization of extraction technology for Xiaoertuire suppository by orthogonal test |
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| CHEN Lin,XU Jia-luan,WANG Jing-xia. Optimization of extraction technology for Xiaoertuire suppository by orthogonal test[J]. Strait Pharmaceutical Journal, 2011, 0(8): 32-34 |
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| Authors: | CHEN Lin XU Jia-luan WANG Jing-xia |
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| Affiliation: | CHEN Lin,XU Jia-luan,WANG Jing-xia(Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310053,China) |
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| Abstract: | OBJECTIVE To optimize the extraction technique of Xiaoertuire Suppository.METHODS The extraction technique was optimized by orthogonal experimental design with the total anthraquinones content as evaluation indicator.Single factor exploration was performed to find out the suitable soaking time,alcohol concentration,the extraction time and the volume of alcoho1,and then L9(34) orthogonal design was adopted to select out the best extraction procedure.RESULTS The best condition for manufacture procedure are ob... |
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| Keywords: | Xiaoertuire Suppository Orthogonal experimental design The total anthraquinones |
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