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| 新型抗2型糖尿病药物钠-葡萄糖协同转运蛋白2抑制剂研究进展 | |
| 引用本文： | 张富东,李玲. 新型抗2型糖尿病药物钠-葡萄糖协同转运蛋白2抑制剂研究进展[J]. 国外医学(药学分册), 2011, 0(5): 375-380 |
| 作者姓名： | 张富东 李玲 |
| 作者单位： | 昆明医学院云南省天然药物重点实验室; |
| 摘 要： | 钠-葡萄糖协同转运蛋白（SGLT）是一类位于小肠黏膜（SGLT1）和肾近曲小管（SGLT2和SGLT1）中的葡萄糖转运基因家族。其中,SGLT2是一种低亲和力的转运蛋白,在肾脏中特异性表达并且在近曲小管葡萄糖重吸收中发挥非常重要的作用。它可以选择性地抑制SGLT2,即可通过增加尿糖的排出来治疗2型糖尿病,是一种创造性的治疗策略。本文介绍了SGLT2抑制剂在2型糖尿病治疗研究方面的最新进展,重点综述了SGLT2抑制剂的作用机制、部分在研SGLT2抑制剂的生物活性数据及临床试验结果。 |
| 关 键 词： | 2型糖尿病 药物治疗 钠-葡萄糖协同转运蛋白,抑制剂 |
Progress in sodium-glucose co-transporter-2 inhibitors:new drugs for treatment of type 2 diabetes |
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| ZHANG Fu-dong,LI Ling. Progress in sodium-glucose co-transporter-2 inhibitors:new drugs for treatment of type 2 diabetes[J]. Foreign Medical Sciences(Section of Pharmarcy), 2011, 0(5): 375-380 | |
| Authors: | ZHANG Fu-dong LI Ling |
| Affiliation: | ZHANG Fu-dong,LI Ling (Yunan Key Laboratory of Pharmacology for Natural Product,Kunming Medical University,Kunming 650031,China) |
| Abstract: | Sodium-glucose co-transporters(SGLT) are a family of glucose transporter found in the intestinal mucosa of the small intestine(SGLT1) and the proximal tubule of the nephron(SGLT1 and SGLT2).The sodium-glucose co-transporter-2(SGLT2) is a low-affinity transporter that is specifically expressed in kidney and plays a very important role in renal glucose reabsorption in the proximal tubule.Selective inhibition of SGLT2 is an innovative therapeutic strategy for the treatment of type 2 diabetes by en-hancing gluc... |
| Keywords: | type2 diabetes drug therapy sodium-glucose co-transporters(SGLT) Inhibitors |
| 本文献已被 CNKI 维普 等数据库收录！ | |