| 清斑胶囊治疗黄褐斑的实验研究 |
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| 引用本文： | 黄恺飞,张国栋,王梅兰,杨辉,许光辉,黄亦琦.清斑胶囊治疗黄褐斑的实验研究[J].海峡药学,2011,23(10):33-35. |
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| 作者姓名： | 黄恺飞 张国栋 王梅兰 杨辉 许光辉 黄亦琦 |
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| 作者单位： | 1. 华侨大学分子药物研究所 泉州362021
2. 厦门市医药研究所 厦门361008 |
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| 基金项目： | 厦门市社会发展创新项目(编号:3502Z20094023) |
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| 摘 要： | 目的探讨清斑胶囊治疗黄褐斑的疗效和作用机制。方法根据文献采用黄体酮肌注法建立黄褐斑实验动物模型，筛选造模成功小鼠。不同浓度分别给药治疗后，观察给药后SOD、MDA、GSH．PX在小鼠血清及肝脏中的变化；同时采用免疫组化法观察清斑胶囊对小鼠皮肤黑色素的影响。结果用药组均能使模型小鼠血清和肝脏中MDA含量降低，SOD、GSH．PX含量明显升高，与模型组比较，差异显著；治疗组皮肤黑色素也明显改善。结论清斑胶囊具有显著的抗氧化作用和良好的治疗黄褐斑作用。
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| 关 键 词： | 清斑胶囊 黄褐斑 |
The experimental research of Qing-ban cupsule on the treatment of chloasma |
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| HUANG Kai-fei,ZHANG Guo-dong,WANG Mei-lan,YANG Hui,Xu Guang-hui,Huang Yi-qi.The experimental research of Qing-ban cupsule on the treatment of chloasma[J].Strait Pharmaceutical Journal,2011,23(10):33-35. |
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| Authors: | HUANG Kai-fei ZHANG Guo-dong WANG Mei-lan YANG Hui Xu Guang-hui Huang Yi-qi |
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| Institution: | HUANG Kai-fei,ZHANG Guo-dong,WANG Mei-lan,YANG Hui,Xu Guang-hui,Huang Yi-qi(Drug R & D Center,Xiamen Medicine Research Institute,Xiamen 361008,China) |
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| Abstract: | OBJECTIVE To investigate the mechanism of Qing-ban Capsule on the treatment of chloasma.METHODS Animal melasma model was established by injection of progesterone according to the literature.SOD,MDA,GSH-PX were observed in mouse serum and liver after the treatment of different drug concentrations.Also the effection of skin melanin was observed by immuno-histochemistry after treated with Qing-ban Capsule.RESULTS SOD,GSH-PX was significantly higher and MDA was decreased in serum and liver after treat with Qing... |
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| Keywords: | Qing-ban capsule Chloasma |
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