| 纳米混悬剂的物理稳定性研究进展 |
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| 引用本文： | 谢向阳,陈晨,廖祥茹,韩亮. 纳米混悬剂的物理稳定性研究进展[J]. 国外医学(药学分册), 2011, 0(5): 369-374 |
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| 作者姓名： | 谢向阳 陈晨 廖祥茹 韩亮 |
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| 作者单位： | 广州军区武汉总医院药剂科; |
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| 基金项目： | 广州军区武汉总医院青年基金(201012) |
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| 摘 要： | 纳米混悬剂具有增加药物溶解度,提高生物利用度,降低毒副作用等特点,有关这方面的研究是目前纳米制剂研究的一个热点,美国FDA至今已批准多个相关产品上市。物理稳定性问题在纳米药物混悬液中比较突出,是制约纳米混悬液研发的重要因素之一。本文就纳米混悬剂物理稳定性所面临的问题、理论机制及其应对策略进行综述。
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| 关 键 词： | 纳米混悬剂 物理稳定性 稳定剂 |
Physical stability of nanosuspensions:research advances |
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| XIE Xiang-yang,CHEN Chen,LIAO Xiang-ru,HAN Liang. Physical stability of nanosuspensions:research advances[J]. Foreign Medical Sciences(Section of Pharmarcy), 2011, 0(5): 369-374 |
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| Authors: | XIE Xiang-yang CHEN Chen LIAO Xiang-ru HAN Liang |
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| Affiliation: | XIE Xiang-yang,CHEN Chen,LIAO Xiang-ru,HAN Liang (Department of Pharmacy,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China) |
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| Abstract: | Nanosuspensions have characteristics of increasing solubility,improving bioavailability,reducing toxicity of drugs,and have become a hotspot in the research area of nanodrugs recently.A few related drugs of nanosuspensions were ap-proved by the FDA of USA up to date.Physical stability is a key issue that limits the research and development of naosuspen-sions.This article reviews the physical stability of nanosuspensions,including their mechanisms and corresponding strategies to overcome the stability proble... |
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| Keywords: | nanosuspensions physical stability stabilizers |
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