| 米诺环素与夫西地酸对98株耐甲氧西林金黄色葡萄球菌的联合药敏研究 |
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| 引用本文： | 张雷,蔡芸,王睿. 米诺环素与夫西地酸对98株耐甲氧西林金黄色葡萄球菌的联合药敏研究[J]. 中国临床药理学杂志, 2011, 27(8) |
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| 作者姓名： | 张雷 蔡芸 王睿 |
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| 作者单位： | 1. 解放军总医院呼吸内科,北京,100853
2. 解放军总医院临床药理研究室,北京,100853 |
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| 基金项目： | 国家自然科学基金资助项目(30873127) |
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| 摘 要： | 目的评价米诺环素与夫西地酸对临床分离到的98株耐甲氧西林金黄色葡萄球菌(MRSA)的联合体外抗菌活性,及两药联用的抗MRSA效应。方法用棋盘法设计,用微量肉汤稀释法,测定不同浓度组合的抗菌药物对98株临床分离MRSA的最低抑菌浓度,并计算部分抑菌浓度指数(FICI),判定联用效应。结果米诺环素与夫西地酸联用后,2种抗菌药物对临床分离得到的98株MR-SA的MIC50显著降低。FICI分布:FICI≤0.5(协同作用)占57.14%;0.54(拮抗作用)为0。结论米诺环素与夫西地酸体外联用对98株临床分离的MRSA体外抗菌效应以协同作用为主;无关作用较少;无拮抗作用。
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| 关 键 词： | 米诺环素 夫西地酸 耐甲氧西林金黄色葡萄球菌 部分抑菌浓度指数 |
Antibacterial activity of minocycline in combination with fusidic acid against 98 strains of methicillin-residtant Staphylococcus aureus in vitro |
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| ZHANG Lei,CAI Yun,WANG Rui. Antibacterial activity of minocycline in combination with fusidic acid against 98 strains of methicillin-residtant Staphylococcus aureus in vitro[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(8) |
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| Authors: | ZHANG Lei CAI Yun WANG Rui |
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| Affiliation: | ZHANG Lei1a,CAI Yun1b,WANG Rui1b(1.a.Department of Respiratory Diseases,b.Department of Clinical Pharmacology,General Hospital of Chinese People's Liberation Army,Beijing 100853,China) |
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| Abstract: | Objective To evaluate the in vitro antibiotic effects of minocycline combined with fusidic acid against 98 strains of methicillin-resistant Staphylococcus aureus(MRSA).Methods The protocol was designed by checkerboard method and the MICs of minocycline alone and combined with fusidic acid against the 98 strains of methicillin-resistant Staphylococcus aureus were determined by broth dilution method.The fractional inhibitory concentration index(FICI) was calculated according to MIC results.The interaction was... |
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| Keywords: | minocycline fusidic acid methicillin-resistant Staphylococcus aureus fractional inhibitory concentration index |
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