| 壳聚糖季铵盐温敏凝胶的制备及性能考察 |
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| 引用本文： | 张平,戴安印,王文喜,单伟光. 壳聚糖季铵盐温敏凝胶的制备及性能考察[J]. 海峡药学, 2011, 23(11): 15-17 |
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| 作者姓名： | 张平 戴安印 王文喜 单伟光 |
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| 作者单位： | 1. 浙江工业大学药学院 杭州 310032
2. 中国人民解放军第一一七医院 杭州 310013 |
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| 摘 要： | 目的 研究壳聚糖季铵盐温敏凝胶及性质.方法 采用试管倾斜法测定胶凝时间,考察壳聚糖季铵盐的浓度、体积比、温度等对胶凝时间的影响,采用吸光度经时变化法测定相变动力学,并用透析法测定载药凝胶的体外释放.结果 56％ GPS/2％ HTCC体积配比1:5、温度37℃时,胶凝时间为3.53min,钙黄绿素载药凝胶具有良好的缓释...
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| 关 键 词： | 温敏凝胶 壳聚糖季铵盐 甘油磷酸钠 钙黄绿素 |
Preparation and characteristics of thermosensitive hydrogel based on quaternized chitosan |
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| ZHANG Ping,DAI An-yin,WANG Wen-xi,SHAN Wei-guang. Preparation and characteristics of thermosensitive hydrogel based on quaternized chitosan[J]. Strait Pharmaceutical Journal, 2011, 23(11): 15-17 |
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| Authors: | ZHANG Ping DAI An-yin WANG Wen-xi SHAN Wei-guang |
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| Affiliation: | ZHANG Ping1,DAI An-yin2,WANG Wen-xi1,SHAN Wei-guang1(1.School of Pharmacy,Zhejiang University of Technology,Hangzhou 310014,2.The 117th Hospital of PLA,Hangzhou 310013,China) |
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| Abstract: | OBJECTIVE To investigate the preparation and characteristics of thermosensitive hydrogel based on quaternized chitosan.METHODS The effect of quaternized chitosan concentration,relative amount and incubation temperature on the gelating time was investigated by tube reverse method,the kinetics of phase change was determined by optical density assay during incubation,and the drug release in vitro was carried out via dialysis method.RESULTS When the ratio of 56% GPS/2% HTCC was 0.2 and the temperature was 37℃,a gelating time of 3.53 minutes was obtained.The thermosensitive hydrogel showed a satisfactory sustained release behavior with the level of 75% in 24h.CONCLUSION All the results demonstrated that the hydrogel based on quaternized chitosan described in the present papar might be a promising thermosensitive drug carries. |
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| Keywords: | Thermosensitive hydrogel Quaternized chitosan βglycerophosphate |
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