| 群体药代动力学在万古霉素治疗药物监测的应用 |
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| 引用本文： | 陈冰,杨婉花.群体药代动力学在万古霉素治疗药物监测的应用[J].中国临床药理学杂志,2011,27(9). |
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| 作者姓名： | 陈冰 杨婉花 |
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| 作者单位： | 上海交通大学医学院,附属瑞金医院,药剂科,上海,200025 |
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| 摘 要： | 群体药代动力学(PPK)应用统计学原理,可综合评价影响药代动力学个体间及个体内差异的各种因素,并进一步利用Bayesian反馈,能较为准确地预测患者个体药代动力学参数。PPK在万古霉素治疗药物监测、给药方案设计调整及药动-药效研究中均有广泛应用。
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| 关 键 词： | 万古霉素 群体药代动力学 治疗药物监测 |
Application of population pharmacokinetics in the therapeutic drug monitoring of vancomycin |
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| CHEN Bing,YANG Wan-hua.Application of population pharmacokinetics in the therapeutic drug monitoring of vancomycin[J].The Chinese Journal of Clinical Pharmacology,2011,27(9). |
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| Authors: | CHEN Bing YANG Wan-hua |
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| Institution: | CHEN Bing,YANG Wan-hua (Department of Pharmacy,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China) |
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| Abstract: | Population pharmacokinetics(PPK),which is based on the principle of statistics,can be used to estimate various inter-and intra-individual factors affect pharmacokinetics.By using Bayesian estimator,PPK can predict individual pharmacokinetic parameters accurately.PPK is widely used in therapeutic drug monitoring,design and regulation of dosage regimen,and pharmacokinetic-pharmacodynamic study of vacomycin. |
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| Keywords: | vancomycin population pharmacokinetics therapeutic drug monitoring |
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