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| 淋病奈瑟菌的耐药性与喹诺酮耐药基因突变的相关性分析 | |
| 引用本文： | 张怡,吴颖,孙爱华.淋病奈瑟菌的耐药性与喹诺酮耐药基因突变的相关性分析[J].海峡药学,2011,23(10):215-218. |
| 作者姓名： | 张怡 吴颖 孙爱华 |
| 作者单位： | 1. 浙江省温岭市中医院 温岭317500 2. 浙江省台州市中西医结合医院 台州317523 3. 浙江医学高等专科学校 杭州310053 |
| 摘 要： | 目的 分析本地区淋病奈瑟菌临床菌株gyrA基因突变与喹诺酮类药物耐药的相关性.方法 采用琼脂稀释法检测37株淋病奈瑟菌临床菌株对6种抗生素的最小抑菌浓度(MIC),PCR法扩增淋病奈瑟菌临床菌株gyrA基因片段并测序.结果37株淋病奈瑟菌临床菌株对大砚霉素、头孢曲松、四环素、青霉素、氧氟沙星和环丙沙星的耐药率分别为0、... |
| 关 键 词： | 淋病奈瑟菌 gyrA基因 突变 序列分析 耐药性 |
Correlation of mutation patterns in gyrA gene in Neisseria gonorrhoeae isolates with quinolone resistance |
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| ZHANG Yi,WU Ying,SUN Ai-hua.Correlation of mutation patterns in gyrA gene in Neisseria gonorrhoeae isolates with quinolone resistance[J].Strait Pharmaceutical Journal,2011,23(10):215-218. | |
| Authors: | ZHANG Yi WU Ying SUN Ai-hua |
| Institution: | ZHANG Yi1,WU Ying2,SUN Ai-hua(1.Wenling chinese traditional hospital,Wenling 317500,China,2.Taizhou hospital of traditional chinese and western medicine,Taizhou 317523,3.Zhejiang medical college,Hangzhou 310053,China) |
| Abstract: | OBJECTIVE To analyze the correlation between mutation in gyrA gene and quinolone resistance in Neisseria gonorrhoeae isolates in the local area.METHODS The MICs of 6 antimicrobials were determined by agar dilution method.PCR and DNA sequencing were conducted to analyze gene of gyrA in 37 isolates.RESULTS The resistance rate of the 37 isolates were 0,0,70.3%,75.7%,91.9% and 97.3%to spectinomycin,cefriaxone,tetracycline,penicillin,ofloxacin and ciprofloxacin respectively.Results of sequencing analysis of gyrA... |
| Keywords: | Neisseria gonorrhoeae GyrA gene Mutation Sequence analysis Resistance |
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