血清腱糖蛋白-C、hs-CRP与急性冠脉综合症的相关性分析

目的 通过观察血清腱糖蛋白-C(TN-C)和高敏C反应蛋白(hs-CRP)在不同类型急性冠状动脉综合征患者血中表达水平,探讨二者与不同类型冠脉综合征的相关性.方法 总共入组诊断为急性冠脉综合症的患者90例,进一步分为两组:急性心肌梗死(AMI)组(n=48),不稳定性心绞痛(UAP)组(n=42),以及另入组稳定性心绞痛60例稳定心绞痛(SAP)组,及健康体检者55例为对照组.采用酶联免疫吸附试验(ELISA法)、放射免疫法分别测定血清TN-C和hs-CRP水平,并在各组间进行比较.结果 AMI组和UAP组TN-C表达水平明显高于SAP组、对照组,差异有统计学意义(P＜0.05);SAP组TN-C水平高于对照组但差异无统计学意义(P＞0.05).AMI组、UAP组和SAP组hs-CRP水平明显高于对照组,差异有统计学意义(均P＜0.05),而AMI组和UAP组hs-CRP较SAP相比差异无统计学意义(均P＞0.05).结论 TN-C、hs-CRP在ACS患者血清中升高,TN-C可作为急性冠状动脉综合征斑块稳定性病变严重程度的预测因子.

The Correlation Between the Serum TN-C,hs-CRP and Acute Coronary Syndrome

Objective To detection the serum level of TN-C and high-sensitivity c-reactive protein (hs-CRP) in patients with different types of acute coronary syndrome,and to explore the correlation of the two inflammatory cytokines with different types of coronary syndrome.Methods We selected 90 patients with acute coronary syndrome,and divided into two group:acute myocardial infarction (AMI) group (n =48) and unstable angina pectoris (UAP) group(n =42).We also selected 60 cases of stable angina pectoris as SAP group,and 55 age and gender marched healthy cases as control group.The serum TN-C and hs-CRP level were measured and compared among groups.Results TN-C was higher in the AMI and UAP groups than that of SAP and control group (P ＜ 0.05).The serum level of TN-C in SAP group is higher than control group,but there was no statistical significance (P ＞ 0.05).The level of hs-CRP was higher in the AMI,UAP and SAP groups than that in the control group,there was no statistical differences among the three groups (P ＞ 0.05).Conclusion TN-C and hs-CRP might be correlated to ACS and TN-C can be used as a predictor of stability of the plaques in patients with ACS.