肺心病急性加重期患者血液流变学及凝血功能指标监测的临床意义

目的 探讨肺心病急性加重期患者血液流变学及凝血功能的变化.方法 选取2014年6月至2016年1月在我院治疗的51例肺心病急性加重期患者为急性加重组,在我院接受治疗的51例恢复期患者为恢复组和社会招募51例健康受试者为正常组,考察肺心病急性加重期患者血液流变学中红细胞计数、红细胞压积、全血高切黏度、全血低切黏度、血浆黏度、血沉,凝血功能中凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶时间(TT)的变化.结果 肺心病急性加重期部分患者的红细胞计数偏离正常值范围,整体肺心病急性加重期患者的红细胞计数与恢复期和正常组受试者差异无统计学意义.肺心病急性加重期患者红细胞压积、全血高切黏度、全血低切黏度、血浆黏度、血沉均较恢复期和正常组受试者的值高,并且差异具有统计学意义(P<0.05).肺心病急性加重期患者的PT、APTT、FIB、TT高出正常值范围,并且与恢复期和正常组相比差异具有统计学意义(P<0.05).结论 肺心病急性加重期的患者血液黏度升高、凝血功能紊乱.因此血液黏度和凝血功能检查,可以作为肺心病急性加重期患者病情判定与评估的一种手段.

Clinical Significance of Hemorheology and Coagulation Function in Patients with Acute Exacerbation of Corpulmonale

Objective To observe the changes of Hemorheology and blood coagulation function in patients with acute exacerbation of chronic pulmonary heart disease.Methods The subjects of the acute exacerbation group who were received medical treatment in our hospital from 06/2014 to 01/2016 are 51 patients with acute exacerbation of chronic pulmonary heart disease, while 51 patients with recovery period for recovery group, and 51 healthy volunteers were recruited as normal group.We measured the changes of red blood cell count, red blood cell pressure volume, whole blood viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte sedimentation rate in blood rheology, prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), thrombin time(TT)in coagulation function in these patients.Results In patients with acute exacerbation of chronic pulmonary heart disease, the red blood cell count was in the range of normal value, and the red blood cell count has no significant difference between acute exacerbation group and the normal group or recovery group in the patients with acute exacerbation of chronic pulmonary heart disease.Packed cell volume, whole blood viscosity, whole blood low cut viscosity, plasma viscosity, erythrocyte sedimentation rate and fibrin are compared with recovery group and the normal group.The subjects showed high values, and the difference is statistically significant (P<0.05).Patients with pulmonary heart disease in acute exacerbation have values of PT, APTT, TT, FIB higher than the normal range of values.When compared with the recovery group and normal group, the difference was statistically significant (P<0.05).Conclusion Increased blood viscosity and coagulation disorders in patients with acute exacerbation of pulmonary heart disease was observed.Therefore, blood viscosity and blood coagulation function tests can be used determine and evaluate the condition of patients with acute exacerbation of pulmonary heart disease.