分子成像在静脉血栓栓塞诊断中的研究与应用进展

静脉血栓栓塞(venous thromboembolism,VTE)主要表现为深静脉血栓形成(deep vein thrombosis,DVT)和肺栓塞(pulmonary embolism,PE),由于症状的非特异性,该疾病很难被确诊.此外,治疗DVT的副作用明显,因此正确诊断静脉血栓栓塞具有重要的临床意义.目前临床上用于诊断静脉血栓栓塞的主要手段包括超声、计算机断层扫描和磁共振成像.近年来,随着分子影像学的快速发展,分子成像在静脉血栓栓塞的诊断中将发挥越来越重要的作用.本文对分子成像的靶点、示踪剂及其用于诊断静脉血栓栓塞的研究进展进行综述.

Research and Application of Molecular Imaging in the Diagnosis of Venous Thromboembolism

Venous thrombosis embolism mainly presents as deep venous thrombosis (DVT) and pulmonary embolism (PE).Due to nonspecific symptoms of VTE,it is difficult to diagnose.In addition,side effects of current treatment of DVT are significant,so it is very important to correctly diagnose VTE.Nowadays,the method of diagnosing VTE mainly includes ultrasound (US),computed tomography (CT) and magnetic resonance imaging (MRI).Recently,with the improvement of molecular medicine,molecular imaging will play more and more important role in the diagnosis of VTE.This review is for discussing currently available and newly evolving targets and tracers for detection of DVT using molecular imaging methods.