慢性肝炎患者血清中降钙素原、C-反应蛋白和IL-10的相关性研究

目的 探讨降钙素原(procalcitonin, PCT)、C-反应蛋白(C-reactive protein,CRP)和白细胞介素-10(interleukin-10,IL-10)在慢性肝炎患者血清中的表达及意义.方法 收集慢性肝炎患者血清并检测血清中降钙素原、C-反应蛋白和IL-10的含量.结果 与对照组相比,慢性活动性肝炎(chronic active hepatitis,CAH) 组和慢性迁移性肝炎(chronic persistent hepatitis,CPH) 组患者血清内降钙素原、C-反应蛋白和IL-10水平显著升高,且CAH组显著高于CPH组,差异具有统计学意义(P<0.05).患者血清降钙素原、C-反应蛋白和IL-10联合检出率显著高于各指标单独检出率.结论 降钙素原、C-反应蛋白和IL-10在慢性肝炎患者的血清中呈过表达状态;且降钙素原、C-反应蛋白和IL-10联合检测对于了解慢性肝炎患者的疾病状态具有重要的临床意义.

Effect of Procalcitonin,C-reactive Protein and IL-10 in Serum of Patients with Chronic Hepatitis

Objective To investigate the expression and significance of procalcitonin(PCT), C-reactive protein (CRP)and interleukin-10 (IL-10) in serum of patients with chronic hepatitis.Methods Serum of patients with chronic hepatitis were collected,and serum levels of procalcitonin, C-reactive protein and IL-10 were measured.Results Compared with the control group, the levels of serum procalcitonin, C-reactive protein and IL-10 in Chronic active hepatitis (CAH) and Chronic persistent hepatitis (CPH) group were significantly increased.Compared with the CPH group, the levels of them in CAH group were significantly increased (P<0.05).The detection rate of serum procalcitonin, C-reactive protein and IL-10 was significantly more sensitivity than that in each single index.Conclusion Calcitonin, C-reactive protein and IL-10 are overexpressed in sera from patients with chronic hepatitis.And the combination of procalcitonin, C-reactive protein and IL-10 has important clinical significance for understanding the disease status of patients with chronic hepatitis.