健康体检人群胃部疾病相关血清学标志物含量分析及异常结果干预策略

目的 通过检测并分析健康体检人群中胃部疾病相关血清学标志物的含量及其影响因素,为胃部疾病的诊断及风险评估提供参考,并探讨胃部疾病相关血清学标志物异常结果的干预策略.方法 选取2015年5月至2016年4月来我院进行健康体检人员555例作为研究对象,测定受检者血清胃蛋白酶原Ⅰ(PGI)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素-17(G-17)和Hp-IgG抗体等指标.结果 在555例体检人群中,随着年龄增长,PGⅠ、PGⅡ、G-17含量上升而PGⅠ/PGⅡ下降.Hp阳性组血清PGIⅠ、PGⅡ、G-17含量较Hp阴性组升高,而PGⅠ/PGⅡ下降.依据血清PGⅠ、PGⅡ、G-17、Hp-IgG抗体四种不同组合进行胃部疾病风险评估:A组354例(63.78％),B组192例(34.59％),C组9例(1.62％).结论 PGⅠ、PGⅡ、G-17指标与年龄、Hp感染呈正相关,健康体检人群中,有较高的血清PG、G-17异常率和Hp感染率,我们依据胃部疾病风险评估情况,应对体检人群进行分层健康管理,并给予积极干预与管理.

Analysis of Levels of Serological Markers of Gastric Disease in Healthy Population Check-up and Reference for Diagnosis and Risk Assessment

Objective To detect and analyze the serological markers of gastric disease levels in healthy people check-up and its influencing factors,to provide reference for diagnosis and risk assessment for gastric disease,and to explore the management measures for people with abnormal gastric.Methods Detect the serum levels of PGⅠ,PGⅡ,G-17 and the anti-Hp-IgG for 555 subjects in routine medical check-up.Results The results showed that the PGⅠ,PGⅡ and G-17 level increased with age whereas PGⅠ/PGⅡ showed a downward trend with age.For the Hp-positive group,the serum levels of PGⅠ、PGⅡ and G-17 were significantly higher than those of the Hp-negative group,while the PGⅠ/PGⅡ was significantly lower.Risk assessment of gastric disease were based on serum levels of PGⅠ,PGⅡ,G-17 and the anti-Hp-IgG:Group A included 354 people (63.78％),Group B included 192 people (34.59％),Group C included 9 people (1.62％).Conclusion The serum level of PG and G-17 increased with age,as well as Hp infection.There were higher serum level of PG,abnormal G-17 and Hp infection rate in general population.We should provide stratified health management,and give active intervention and treatment.