CYP2C19基因多态性与肺鳞癌发病的相关性

目的 探讨CYP2C19基因多态性与肺鳞癌发病的相关性.方法 选取2015年6月至2015年12月军事医学科学院附属医院收治的肺癌患者.入院后完善病例资料,检测CYP2C19基因表型,单因素及多因素分析CYP2C19基因与肺鳞癌发病的相关性,分析其是否为肺鳞癌发病的独立危险因素.结果 本研究共入组200例肺癌患者,其中肺鳞癌59例.肺鳞癌中,快代谢型患者显著多于其它类型的肺癌患者(66.10% vs.46.10%).多因素分析结果表明快代谢型患者与慢代谢型患者相比,其发生肺鳞癌的风险增大约5.9倍(OR=5.987,95%CI:1.118~3.272).结论 CYP2C19快代谢型改变是肺鳞癌发病的独立危险因素.

The Relationship Between CYP2C19 Gene Polymorphismand the Squamous Cell Lung Cancer

Objective To investigate the relationship between CYP2C19 gene polymorphism and the pathogenesis of squamous cell lung cancer.Methods The lung cancer patients treated in the Affiliated Hospital of Academy of Military Medical Sciences between June 2015 and December 2015 were enrolled.After admission, the case data were completed, the CYP2C19 gene phenotype was identified.univariate and multivariate were used to analyze the correlation between CYP2C19 gene and squamous cell lung cancer and determine whether it is an independent risk factor for squamous cell lung cancer.Results In this study, 200 patients with lung cancer were enrolled, including 59 cases of squamous cell lung cancer.In patients with squamous cell lung cancer, the number of fast metabolites was significantly higher than that of other lung cancer patients (66.10% vs.46.10%).Multivariate analysis showed that patients with fast metabolites had a 5.9-fold increased risk of squamous cell lung cancer compared with slow-metabolized patients (OR=5.897, 95% CI: 1.118-8.126).Conclusion This study confirmed fast metabolic change of CYP2C19 is an independent risk factor for the development of squamous cell lung cancer.