血清超敏C反应蛋白和心肌钙蛋白T检测对冠心病患者经皮冠状动脉介入治疗的临床价值探讨

目的 探讨血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)和心肌钙蛋白T(cardiac troponin T,cTn-T)检测对冠心病(coronary heart disease, CHD)患者经皮冠状动脉介入治疗(percutaneous coronary intervention, PCI)的临床价值.方法 选取2014 年1月至2016年3月期间本院收治的CHD患者79例作为研究对象,根据治疗方式的不同将按随机数字表法把患者分为观察组40例和对照组39例,观察组CHD患者40例行PCI术治疗,对照组CHD患者39例给予常规药物治疗.检测并记录两组患者治疗前后血清hs-CRP和cTn-T水平,同时详细记录观察组行PCI术前后相关信息.结果 治疗前两组患者hs-CRP、cTn-T比较差异不明显,不具有统计学意义(均P>0.05);治疗后hs-CRP、cTn-T与治疗前相比较均显著升高,均差异具有统计学意义(均P<0.05);与对照组69.23%(27/39)满意率相比较观察组为87.50%(35/40)显著较高,差异具有统计学意义(χ2=3.261,P<0.05);观察组的不良反应发生率为7.50%(3/40)显著小于对照组15.38%(6/39),差异具有统计学意义(χ2=4.524,P<0.05).结论 对于hs-CRP、cTn-T指标水平较高的CHD患者在行PCI术治疗的效果显著,虽仍可诱发一定程度的不良反应,但应用价值明显,值得临床推广.

The Discussion on Clinical Values of Serum High Sensitive C ReactiveProtein and Cardiac Troponin T Measures in Patients with CoronaryHeart Disease After Percutaneous Coronary Intervention

Objective To discuss the clinical values of serum hs-CRP and cTn-T measures in patients with CHD after PCI.Methods 79 cases of CHD patients were selected in our hospital from Jan 2014 to Mar 2016 as the research objects.According to the different treatment methods these patients were randomly divided into the observation group(40 cases) and the control group(39 cases), with the observation group CHD patients of 40 cases were treated with PCI, while the control group CHD of 39 cases were given conventional drug treatment.We measured and recorded the serum levels of hs-CRP and cTn-T before and after treatment in two groups of patients, and at the same time, the observation group was recorded in detail information pre and post the PCI.Results Before treatment, the two groups of patients′ cTn-T, hs-CRP levels were not significantly different,(P>0.05).After treatment, cTn-T and hs-CRP levels were significantly increased compared with the pre treatment,(P<0.05).Compared with the values of control group 69.23%(27/39), the observation group has satisfaction rate 87.50%(35/40) which was significantly higher,(χ2=3.261, P<0.05).The incidence of adverse reactions in the observation group was 7.50%(3/40) which was significantly lower than that of the control group of 15.38%(6/39),(χ2=4.524,P<0.05).Conclusion High level Hs-CRP, cTn-T CHD patients have significant effects with the treatment of PCI.Even though it induces a certain degree of adverse reaction, its clinical value is obvious and worth the clinical promotion.