儿童百日咳与支气管哮喘关系的研究进展

支气管哮喘(哮喘)是一种多因素异质性疾病，严重影响儿童的身心健康。对于其发病原因及机制的研究一直是学者们关注的重点。近年来，呼吸道合胞病毒、鼻病毒、肺炎支原体等病原体感染与哮喘的关系逐渐明确，但是百日咳与哮喘之间的关系尚不明确。有研究认为百日咳杆菌感染后可诱导IgE的产生、激活Th2细胞并诱导Th17免疫应答，加强中性...

Update on the relationship between pertussis and bronchial asthma in children

Bronchial asthma(asthma)is a multifactorial heterogeneous disease that seriously affects the physical and mental health of children.Recently,many scholars focus on the cause and mechanism of asthma.It had been confirm that respiratory syncytial virus,rhinovirus,Mycoplasma pneumoniae and some other pathogens were associated with asthma.However,the relationship between pertussis and asthma is unclear.Some studies have suggested that pertussis infection can induce the production of IgE,activate Th2 cells and induce the Th17 immune response,strengthen the inflammatory infiltration of neutrophils to the airways,promote airway remodeling,damage airway ciliated epithelium structure and causing respiratory system microecological imbalanceto contributeto the asthma.It may also possible inhibit airway hyperresponsiveness through the Toll-like receptor-9 pathway.However some studies have suggested that pertussis infection has nothing to do with asthma.So,to better understand the relationship between whooping cough and asthma,we reviewed the recent literature and explained it in this study in order to raise pediatrician′s awareness and control the occurrence and development of asthma.