血清壳多糖酶3样蛋白1、肝纤维化4项及AFP的检测在不同肝脏疾病中的应用价值探讨

目的 探讨血清壳多糖酶3样蛋白1(CHI3L1)、肝纤维化4项及甲胎蛋白(AFP)在不同肝脏疾病中的应用价值.方法 选取172例符合条件的慢性乙型肝炎病毒感染者,分为慢性乙型肝炎组、肝硬化组和肝癌组.收集同期健康体检者30例作为正常对照组.比较各组间指标的差异,采用受试者工作特征(ROC)曲线分析各指标鉴别诊断效能.采...

Study on the application value of serum chitosan enzyme 3-like protein 1,liver fibrosis 4 items and AFP detection in different liver diseases

Objective To investigate the determination of serum chitinase 3-like protein 1(CHI3L1),hyaluronic acid(HA),laminin(LN),Ⅲ-procollagen(PC Ⅲ),Ⅳ-collagen(Ⅳ-C) and alpha fetoprotein(AFP) for the application in patients with different liver diseases. Methods A total of 172 patients with chronic hepatitis B infection were selected and divided into chronic hepatitis B group,liver cirrhosis group and liver cancer group. 30 healthy subjects in the same period were treated as control group. The serum CHI3L1,HA,LN,PC Ⅲ,Ⅳ-C and AFP levels were compared among different groups. Receiver operating characteristic(ROC) curve was used to analyze the efficacy of CHI3L1,HA,LN,PC Ⅲ,Ⅳ-C and AFP in the diagnosis and antidiastole between different groups. Results The levels of CHI3L1,HA,LN,PC Ⅲ and Ⅳ-C were significantly higher in liver cirrhosis group and liver cancer group than that in chronic hepatitis B group and control group(P < 0. 05). The level of AFP was significantly higher in liver cancer group than that in other groups,with the difference statistically significant(P < 0. 01),and the AUC of AFP in the diagnosis of liver cancer was 0. 912. ROC curve showed that the AUC of CHI3L1 in the antidiastole between liver cirrhosis group and chronic hepatitis B group was 0. 853,and the AUC between chronic hepatitis B group and control group was 0. 845,both of which have good antidiastole efficacy. Spearman correlation analysis showed that the severity of liver disease was positively correlated with each serological indicators(P < 0. 05). Conclusion CHI3L1,HA,LN,PC Ⅲ,Ⅳ-C and AFP can be used as diagnostic and antidiastole parameters for different liver diseases and is worthy of further study.