阻塞性睡眠呼吸暂停综合征患者心外膜脂肪组织厚度与左心室几何构型的相关性

目的:探讨心外膜脂肪组织(EAT)厚度与阻塞性睡眠呼吸暂停综合征(OSAS)患者左室几何构型的相关性。方法:收集2019年1-12月就诊于山西医科大学第一医院呼吸科睡眠室的OSAS患者221例，依据左室质量指数(LVMI)和相对室壁厚度(RWT)分为4组：正常构型(NG)组110例，向心性重构(CR)组56例，向心性肥...

The relationship between left ventricular geometry and epicardial adipose tissue thickness in patients with obstructive sleep apnea syndrome

Objective To investigate the relationship between epicardial adipose tissue(EAT)thickness and left ventricular geometry in patients with obstructive sleep apnea syndrome(OSAS).Methods Two hundred and twenty-one OSAS patients were enrolled consecutively from the First Hospital of Shanxi Medical University from January to December 2019.According to left ventricular mass index(LVMI)and relative wall thickness(RWT),OSAS patients were divided into 4 groups based on the left ventricular geometry:110 with normal geometry(NG group),56 with concentric remodeling(CR group),32 with concentric hypertrophy(CH group),and 23 with eccentric hypertrophy(EH group).The patients were examineel by echocardiography,the left ventricular end diastolic diameter,LVMI,interventricular septal thickness,left ventricular posterior wall thickness,left ventricle ejcetion fraction,E/A were collected.Age,systolic blood pressure(SBP),diastolic blood pressure(DBP),apnea hypopnea index(AHI),nocturnal lowest oxygen saturation(Lowest-SaO₂),nocturnal mean oxygen saturation(Mean-SaO2),the percentage of the time that oxygen desaturation below 90%(T90),oxygen desaturation index(ODI),triglyceride(TG),total cholesterol(TC),EAT thickness and the echocardiography parameters were compared among the four groups.The relationships between EAT thickness and the above-mentioned parameters and left ventricular geometry were analyzed by univariate and multivariate linear regressions.Results①The higher EAT thickness was found in the CH group[(0.50±0.09)cm]and EH group[(0.46±0.07)cm]compared with the NG group[(0.33±0.11)cm]and CR group[(0.36±0.15)cm](all P<0.05).In addition,age,SBP,DBP,AHI,ODI,T90,LVMI,RWT and E/A ratio were all significantly different among the groups(all P<0.05).②Univariate linear regression analysis showed that EAT thickness was positively correlated with age,SBP,DBP,AHI,TG,TC and LVMI,RWT,left ventricular geometry,and negatively correlated with Mean-SaO2 and Lowest-SaO2.③Multivariate linear regression analysis showed that EAT thickness was independently correlated with AHI,TG,TC and left ventricular geometry.Conclusions EAT is independently related to abnormal left ventricular geometry,suggesting that EAT may be involved in the process of left ventricular remodeling.