| Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy |
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| 引用本文： | Lei Du,Xuan Qian,Yuan Li,Xi-zhi Li,Lin-lin He,Liu Xu,Yi-qi Liu,Cheng-cheng Li,Pu Ma,Fang-lin Shu,Qian Lu,Xiao-xing Yin. Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy[J]. Acta pharmacologica Sinica, 2021, 0(2): 242-251 |
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| 作者姓名： | Lei Du Xuan Qian Yuan Li Xi-zhi Li Lin-lin He Liu Xu Yi-qi Liu Cheng-cheng Li Pu Ma Fang-lin Shu Qian Lu Xiao-xing Yin |
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| 作者单位： | Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy |
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| 基金项目： | supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.15KJA310005,No.19KJA460008);the National Natural Science Foundation of China(No.81973377);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Science and Technology Project of Xuzhou(No.KC18202). |
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| 摘 要： |
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| 关 键 词： | diabetic nephropathy SIRT1 Yin yang 1 ACETYLATION epithelial-mesenchymal transition db/db mice human proximal tubular epithelial cell line HK-2 resveratrol SRT1720 EX527 |
Sirt1 inhibits renal tubular cell epithelial-mesenchymal transition through YY1 deacetylation in diabetic nephropathy |
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| Abstract: | Silent information regulator 1(Sirt1)is a deacetylase,which plays an important role in the occurrence and development of diabetic nephropathy(DN).Our previous s... |
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