阿魏酸哌嗪联合血液透析治疗肾综合征出血热急性肾衰竭的临床观察

目的:观察阿魏酸哌嗪联合血液透析治疗肾综合征出血热急性肾衰竭的临床疗效及其作用机制。方法:肾综合征出血热伴急性肾衰竭患者28例按抽签方式随机分为治疗组和对照组,各14例,对照组行血液透析等常规治疗方案,治疗组在对照组治疗基础上服用阿魏酸哌嗪,200 mg tid,观察治疗前后临床体征、肾功能、血浆内皮素(ET)、循环内皮细胞数量的变化。结果:治疗组无死亡病例,且全部治愈;对照组死亡1例,但2组死亡率比较无统计学差异(χ²=1.04,P>0.05;χ²=3.36,P>0.05)。在血肌酐(Scr)、尿素氮(BUN)恢复正常时间、尿蛋白消失时间、血浆ET-1、循环内皮细胞等方面,治疗组明显优于对照组(P<0.05)。结论:阿魏酸哌嗪能保护血管内皮功能,促进肾综合征出血热急性肾衰竭患者康复。

Clinical observation on piperazine ferulate combined with hemodialysis for patients with hemorrhagic fever with renal syndrome

OBJECTIVE To observe the clinical efficacy and the mechanism of piperazine ferulate combined with hemodialysis therapy against hemorrhagic fever with renal syndrome. METHODS Twenty-eight patients suffering from hemorrhagic fever with renal syndrome were randomly divided into treatment group and control group by ballot,with fourteen patients in each group. The patients in control group received hemodialysis and other conventional treatments. Besides of routine therapies including hemodialysis in the control group, all patients in the treatment group also took piperazine ferulate, two hundred milligrams each time and three times each day. Clinical signs, renal function, plasma endothelin (ET) and change of circulating endothelial cell number were observed before and after treatments.RESULTS There were no death in treatment group and all patients were cured. One patient died in control group. But there was no significant difference (χ² =1.04, P>0.05; χ²=3.36, P>0.05) between the two groups. In terms of the time for serum creatinine (Scr) and blood urea nitrogen (BUN) to resume normal and urine protein disappeared, plasma ET-1, circulating endothelial cells etc, the treatment group was significantly superior to control group (P<0.05).CONCLUSION Piperazine ferulate can protect endothelial function and promote the recovery of patients suffering from hemorrhagic fever with renal syndrome.