Ca2+-induced erythrocyte hyperpolarization in patients with tumors of different localization |
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| Authors: | I. V. Petrova I. B. Sokolova E. A. Stepovaya M. V. Kolosova V. I. Koryukin V. E. Gol'dberg M. B. Baskakov M. A. Medvedev V. V. Novitskii |
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| Affiliation: | (1) Institute of Pharmacology, Siberian Medical State University, Tomsk;(2) Institute of Oncology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk |
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| Abstract: | In patients with lung cancer and malignant tumors of the head and neck, erythrocyte hyperpolarization associated with the opening of Ca2+-activated potassium channels develops with lower rate and amplitude compared with that in healthy donors. Restoration of normal membrane potential is Ca2+-ATPase-dependent. The rate of restoration is significantly higher in patients with tumors. Two groups with different hyperpolarization response and their dynamics during chemotherapy were identified in patients with lung cancer. Ca2+-induced erythrocyte hyperpolarization and its dynamics during cytostatic therapy depend on tumor localization and histological type. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 77–80, January 1999 |
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| Keywords: | Ca 2+-activated potassium channel erythrocyte lung cancer head and neck tumors |
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