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Ca2+-induced erythrocyte hyperpolarization in patients with tumors of different localization
Authors:I. V. Petrova  I. B. Sokolova  E. A. Stepovaya  M. V. Kolosova  V. I. Koryukin  V. E. Gol'dberg  M. B. Baskakov  M. A. Medvedev  V. V. Novitskii
Affiliation:(1) Institute of Pharmacology, Siberian Medical State University, Tomsk;(2) Institute of Oncology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk
Abstract:In patients with lung cancer and malignant tumors of the head and neck, erythrocyte hyperpolarization associated with the opening of Ca2+-activated potassium channels develops with lower rate and amplitude compared with that in healthy donors. Restoration of normal membrane potential is Ca2+-ATPase-dependent. The rate of restoration is significantly higher in patients with tumors. Two groups with different hyperpolarization response and their dynamics during chemotherapy were identified in patients with lung cancer. Ca2+-induced erythrocyte hyperpolarization and its dynamics during cytostatic therapy depend on tumor localization and histological type. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 1, pp. 77–80, January 1999
Keywords:Ca 2+-activated potassium channel   erythrocyte    lung cancer    head and neck tumors
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