| 健脑益智胶囊水提部位精制工艺研究 |
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| 引用本文： | 郭东艳,;覃鸿恩,;赵晓平,;吕杨,;何萌萌.健脑益智胶囊水提部位精制工艺研究[J].陕西中医学院学报,2014(5):66-69. |
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| 作者姓名： | 郭东艳 ;覃鸿恩 ;赵晓平 ;吕杨 ;何萌萌 |
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| 作者单位： | [1]陕西中医学院药学院,陕西咸阳712046; [2]陕西中医学院附属医院,陕西咸阳712000 |
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| 基金项目： | 陕西省科技厅资助项目（2011KTCL03-02） |
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| 摘 要： | 目的考察健脑益智胶囊水提部位的醇沉工艺条件。方法以药液浓度、醇沉浓度和醇沉时间为考察因素,采用Box-Behnken中心组合试验设计,响应面分析法,以葛根素转移率为评价指标,确定醇沉的最佳工艺条件。结果最佳工艺条件为:药液浓度为0.72 g/mL,醇沉浓度为60%,醇沉时间为36 h,葛根素转移率可达到99%以上。结论采用醇沉工艺精制健脑益智胶囊水提液部分,具有较好的可行性和有效性,可节约成本并提高产品质量。
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| 关 键 词： | 健脑益智 水提液 醇沉 响应面分析 |
Study on Water Extraction of Refining Jiannao Yizhi Capsule |
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| Institution: | Guo Dongyan , Tan Hong＇en , Zhao Xiaoping, Lv Yang , He Mengmeng ( 1. School of medicine, Shaanxi University of Chinese Medicine Xianyang, Shaanxi 712046; 2. Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712000) |
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| Abstract: | Objective to investigate the Jiannao Yizhi capsules water extract alcohol precipitation process. Method for liquid concentration,the concentration of alcohol precipitation and precipitation time as factors,the combination test design of Box- Behnken center,the method of response surface analysis,the transfer rate of Puerarin as index,the optimum process conditions were determined and alcohol precipitation. Results the optimum conditions： the concentration of0. 72 g /mL,alcohol concentration of 60%,ethanol precipitation time 36 h,puerarin transfer rate can reach above 99%.Conclusion the sinking process of refining Jiannao Yizhi capsules water extract by alcohol,and is feasible and effective,and can save cost and improve product quality. |
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| Keywords: | Jiannao Yizhi Water-extraction alcohol-precipitation response surface analysis |
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