| 犬快速心房起搏房颤模型肺静脉及心房组织心肌纤维化定量分析 |
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| 引用本文： | 马芹,高玉龙,王健,马长生. 犬快速心房起搏房颤模型肺静脉及心房组织心肌纤维化定量分析[J]. 国外医学:心血管疾病分册, 2009, 0(3): 181-183 |
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| 作者姓名： | 马芹 高玉龙 王健 马长生 |
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| 作者单位： | 首都医科大学附属北京安贞医院抢救中心; |
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| 摘 要： | 目的：探讨持续性房颤时肺静脉及心房结构重构的变化，以期进一步阐明房颤的发病机制。方法：将18只健康杂种犬随机分为对照组（n=8）和房颤组（n=10）。房颤组犬以400次／分快速心房起搏制备房颤模型。10周后分别取两组犬的左上肺静脉（LSPV）、左房峡部（LAI）、右心耳（RAA）处心肌进行心肌纤维定量分析，并进行对照研究。结果：房颤组各部位Ⅲ型胶原含量显著高于对照组，分别为肺静脉3301．97±309．70对1404．56±178．02、左心房峡部2477．86±190．43对1479．20±187．17、右心耳2045．92±139．43对1417．07±139．43。房颤组Ⅲ型胶原的含量肺静脉组织显著高于左房峡部，左房峡部显著高于右心耳（P〈0．05），且存在明显的梯度差。结论：快速心房起搏可导致肺静脉和心房组织纤维化程度增加，发生结构重构。肺静脉、左房峡部和右心耳心肌纤维化的程度存在显著的梯度差异，可能是结构重构的关键部位，在房颤维持过程中起重要作用。
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| 关 键 词： | 快速心房起搏 心肌纤维化 结构重构 杂种犬 |
Quantitative analysis of collagen fiber in pulmonary veins and atria in dog models with rapid atrial fibrillation |
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| Ma Qin,Gao Yu-long,Wang Jian,Ma Chang-sheng. Emergency Centre Anzhen Hospital,the Attached Hospital of Capital University of Medical Sciences. Quantitative analysis of collagen fiber in pulmonary veins and atria in dog models with rapid atrial fibrillation[J]. , 2009, 0(3): 181-183 |
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| Authors: | Ma Qin Gao Yu-long Wang Jian Ma Chang-sheng. Emergency Centre Anzhen Hospital the Attached Hospital of Capital University of Medical Sciences |
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| Affiliation: | . (Emergency Centre Anzhen Hospital, the Attached Hospital of Capital University of Medical Sciences) |
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| Abstract: | Objective:To investigate structural remodeling in pulmonary vein and atria during persistent atrial fibrillation and clarify the mechanism of atrial fibrillation further. Methods:Eighteen adult mongrel dogs were randomly divided into two groups:the control group(n=8)and the acute atrial fibrillation group(n=10).Atrial fibrillation models were induced through rapid atrial pacing at the rate of 400 beats per minites for 10 weeks in experimental group. Tissues were obtained from left superior pulmonary vein(LS... |
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| Keywords: | Rapid atrial pacing （RAP） Fibrosis Structural remodeling Mongrel dogs |
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