Familial erythroid multinuclearity

1. Dysplastic erythropoiesis, erythrocyte gigantism and giant plurinucleatedred cell precursors in the bone marrows of a woman and all 3 of her children aredescribed. All 4 subjects have mild anemia without symptoms therefrom.

2. The changes described are apparently irreversible but do not representmalignant nor agonal change.

3. It is likely that these findings represent an inherited anomaly of erythropoiesis. The nature of the genetic transmission cannot be determined from thesestudies.

4. We propose the designation familial erythroid multinuclearity to describethis anomaly of red cell production.

Submitted on March 20, 1951 Accepted on August 28, 1951