Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with early onset Alzheimer's disease fails to reveal mutations in the beta-amyloid sequence. |
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| Authors: | F Crawford J Hardy M Mullan A Goate D Hughes L Fidani P Roques M Rossor M C Chartier-Harlin |
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| Affiliation: | Department of Biochemistry, St. Mary's Hospital Medical School, London, U.K. |
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| Abstract: | A mutation within exon 17 at codon 717 of the beta-amyloid protein precursor (APP) gene is one cause of early onset familial Alzheimer's disease. Direct sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene in 14 families with familial early onset Alzheimer's disease without the known pathogenic mutation (APP717) failed to reveal other mutations within the beta-amyloid sequence in this form of the disorder. |
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