依达拉奉对急性心肌梗死溶栓后再灌注损伤的影响

目的探讨依达拉奉(edaravone)对急性心肌梗死(AMI)溶栓后再灌注损伤的影响。方法60例AMI患者被随机分为治疗组与对照组,治疗组给予依达拉奉静滴2周。观察两组血管再通率及再灌注心律失常发生率,并记录每例患者入院即刻和7 d1、4 d的12导联心电图,用QRS记分法进行QRS记分,预测梗死面积,于治疗14 d后,行超声心动图检查测定心功能。结果两组血管再通率比较无明显差异(P>0.05);两组治疗后再灌注心律失常发生率、治疗后14 dQRS记分、梗死面积、左室射血分数(LVEF),均有显著性差异(P<0.05,P<0.01)。结论依达拉奉具有降低AMI溶栓后心肌再灌注损伤的作用,并且能改善近期心脏功能。

The Effect of Edaravone on Reperfusion Trauma after Thrombolysis in Acute Myocardial Infarction

Objective To evaluate the Effect of Edaravone on reperfusion trauma after thrombolysis in acute myocardial infarction （AMI）. Methods 60 cases of AMI were randomly divided into two groups. Therapy group add edaravone drop- in for two weeks. To observed recanalization rate and the incidence of reperfusion arrhythmias, the conventional 12 leads electrocardiogram （ECG） was recorded on admission and 7, 14 days after the infarction size was scored by the QRS scoring system proposed by Wagner. The cardiac systolic and diastolic functions were assessed by ultra- cardio- graph checking on 14 days after the treatment. Results Recanalization rate of the two groups showed no significant dif- ference （P 〉 0.05） ;The two groups after the treatment the incidence of reperfusion arrhythmia,treatment 14 days after the QRS score,infarct size,left ventricular ejection fraction （LVEF） were significant difference （P 〈 0.05, P 〈 0.01 ）. Conclusion Treatment with edaravone might have beneficial effect on reperfusion trauma after thrombolysis in AMI, and improve cardiac function in hospital.