类泛素化修饰在脊髓损伤中作用的研究进展

脊髓损伤临床常见且预后大多较差,损伤后病理过程相当复杂。近年来,神经系统疾病中类泛素修饰蛋白(SUMO)的作用越来越受到关注。SUMO是一类最新发现的蛋白质翻译后修饰蛋白,类泛素化修饰在人体中多个生理和病理生理学活动过程中发挥重要作用。研究结果显示脊髓损伤后脊髓水肿、脊髓缺血/再灌注、氧化应激和炎性反应等过程中多种重要的蛋白分子均存在SUMO化修饰调控机制,SUMO相关蛋白的应用亦被证明可调节氧化应激延缓神经元的死亡,其与抗氧化剂等其他脊髓治疗性化合物联合使用有望用于预防缺血性损伤的神经保护,本文拟对脊髓损伤过程中有关SUMO化修饰的最新研究作一综述。

Research progress of small ubiquitin-related modifierylation in the regeneration of spinal cord injury

Spinal cord injury is common in clinic with poor prognosis,and its pathological process is very complicated.In recent years,small ubiquitin-related modifier(SUMO)receives more and more attention in nervous system diseases,and has been newly discovered as a kind of post-translational modification protein.Sumoylation plays an important role in many physiological and pathophysiological processes in human body.It has been found that many important protein molecules can be sumoylated and involved in the process of spinal cord edema,spinal cord ischemia/reperfusion,oxidative stress and inflammatory reaction after spinal cord injury.SUMO-related proteins have also been proved to regulate oxidative stress and retard the neuronal death.And its combination with antioxidants and other spinal cord therapeutic compounds is expected to be used to prevent ischemic injury.In this paper,the latest research on SUMO modification in spinal cord injury is reviewed.