调气活血中药治疗萎缩性胃炎的疗效评价及其对胃黏膜血流的影响

目的：观察调气活血中药治疗萎缩性胃炎（CAG）伴肠化生的疗效及其对胃黏膜血流的影响。方法：将93例CAG伴肠化生患者随机分为治疗组和对照组，治疗组予调气活血方加减，对照组予参芍胃安颗粒。评价治疗前后临床症状及病理隋况的改善，同时随机选择每组患者各30例，检测并比较治疗前后胃黏膜血流情况。结果：临床症状总有效率，治疗组为87．0％，对照组为80．9％；病理情况总有效率，治疗组为71．7％，对照组为74．5％。组间临床及病理疗效比较均无显著性差异（P〉0．05）。两组患者治疗后胃窦大弯、小弯、前壁、后壁黏膜血流较治疗前均有明显增加，其差异均具有统计学意义（P〈0．01），而两组患者治疗后其胃黏膜血流无明显差异（P〉0．05）。结论：以调气活血立法的参芍胃安颗粒和调气活血方加减都能有效改善CAG病理、缓解其症状，提示调气活血中药改善CAG患者胃黏膜血流可能是其取效的重要机制之一。

Effects of Qi-Regulating and Blood-Activating Herbs on Chronic Atrophic Gastritis and Gastric Mucosal Blood Flow

Objective： To investigate the effects of qi-regulating and blood-activating herbs on chronic atrophic gastritis （CAG） with intestinal metaplasia and gastric mucosal blood flow. Methods： Ninety-three CAG patients with intestinal metaplasia were randomly divided into treatment group and control group. The treatment group were treated by ＂Tiaoqi Huoxue Decoction ＂ and the control group were treated by ＂Shenshao Weian Granule＂. The clinical symptoms and pathology were observed and the gastric mueosal blood flow of 30 cases selected randomly from each group was detected before and after treatment. Results： The clinical effective rates were 87.0% and 80.9% and the pathological effective rates were 71.7% and 74.5% respectively in treatment group and control group. There was no significant difference in clinical and pathological effect between the two groups （P 〉 0. 05）. The gastric mueosal blood flow of the both groups after treatment was obviously improved in greater curvature, lesser curvature, anterior wall and posterior wall of gastric antrum compared with that before treatment（ P 〈 0.01 ）. While there was no significant difference in gastric mucosal blood flow between the two groups after treatment （ P 〉 0.05 ）. Conclusion： Both ＂ Tiaoqi Huoxue Decoction ＂ and ＂Shenshao Weian Granule ＂ can effectively improve the pathological condition and clinical symptoms of CAG patients, indicating that the improvement of gastric mueosal blood flow may be one of the important mechanisms of qi-regulating and blood-activating herbs in the treatment of CAG.