异丙酚对犬实验性心肌梗死左心功能的影响

目的 :研究不同剂量异丙酚对犬实验性心肌梗死左心功能影响。方法 :杂种犬 18只随机分为三组 :NS组(生理盐水对照组 ,2ml·kg- 1·h- 1)、HP组 (高剂量异丙酚组 ,10mg·kg- 1·h- 1)和LP组 (低剂量异丙酚组 ,5mg·kg- 1·h- 1)。开胸阻断左冠动脉前降支 3 0、60、12 0、180及 2 40min ,测定和计算二尖瓣前叶舒张早期关闭斜率(MVEF)、二尖瓣前叶E峰到室间隔左室面的垂直距离 (EPSS)、心搏量 (SV)、心输出量 (CO)和射血分数 (EF)。结果 :NS组的MVEF、SV、CO和EF呈进行性下降 ,EPSS呈进行性上升 ,而实验组 (尤其是HP组 )的变化趋势不如NS组明显 ;LAD阻断 60、12 0、180及 2 40min时实验组MVEF、SV、CO和EF显著高于同时间点NS组指标 (P <0 .0 5) ,而EPSS显著低于同时间点NS组指标 (P <0 .0 5)。结论 :异丙酚对犬实验性心肌梗死的左心功能有一定的保护作用

Effects of propofol on left ventricular function in dogs with experimental myocardial infarction

Objective To investigate the effect o f propofol on left ventricular function in dogs with experimental myocardial inf arction.Methods 18 hybrid dogs (10～14kg) were divided ran d omly into three groups:NS group (normal saline,2 ml·kg -1 ·h -1 ),H P group (high-dose propofol,10 mg·kg -1 ·h -1 ),LP group (low-dose p ropofol,5 mg·kg -1 ·h -1 ).30?60?120?180 and 240 min following lef t anterior descending coronary artery (LAD) occlusion,left ventricular function was assessed by measurement of maximal velocity of early filling(MVEF)?E point to septal separation(EPSS)?stroke volume(SV)?cardiac output(CO) and ejection fraction(EF) with Doppler echocardiography. Results With L AD occlusion,the values of MVEF?SV?CO and EF were decreased and the value of EPSS was increased in NS group,while these values in HP or LP group were not cha nged as markedly as in NS group. 60?120?180 and 240 min following LAD occlusio n in HP or LP group, the values of MVEF?SV?CO and EF were signifcantly higher than that at the correspording time points in NS group(P<0.05),while the va lue of EPSS was lower significantly than that in NS group(P<0.05).Conclusions Propofol can protect left ventricular function in dogs with experimental myocardial infarction.