银杏叶软胶囊处方工艺研究

目的：确定银杏叶软胶囊的最佳处方工艺。方法：通过对软胶囊囊壳和内容物处方及软胶囊压制和干燥关键工艺的优化研究,确定银杏叶软胶囊的最佳处方工艺。结果：银杏叶软胶囊的最佳处方工艺：胶囊壳处方为明胶：水：甘油=1：0.9：0.4,添加二氧化钛为0.4%,柠檬黄为0.05%、亮蓝为0.10%和诱惑红为0.15%;内容物处方为银杏叶提取物为（粒径120目）16%,蜂蜡为5%和大豆油为79%;控制软胶囊囊壳厚度0.7mm;干燥工艺采用温度20℃,相对湿度为30%～35%,干燥24h。结论：本处方工艺稳定、可靠,适于银杏叶软胶囊的工业化生产。

Study on formulation and technology of Gingko Softgel

Objective：To confirm the best formulation and preparation technology for Gingko Softgel.Methods：Studied the softgel formulation of dry shell and filling materials,and the critical process of encapsulating and drying to confirm the best formulation and preparation technology for Gingko Softgel.Results：The best formulation and preparation technology：softgel dry shell formulation was：Gelatin：Water：Glycerine=1：0.9：0.4,besides added in Titanium Dioxide was 0.4%,Tartrazine was 0.05%,and Brilliant Blue FCF was 0.10%,Allura Red AC was 0.15%;the filling formulation was Ginkgo Leaves Extract was（mesh size was 120 meshes） 16%,Beeswax was 5% and Soybean was 79%;the shell thickness was 0.7 mm under control;for drying process,the temperature was 20℃,relative humidity was 30%-35%,and drying time was 24 hours.Conclusion：This formulation and preparation technology is stable and reliable,suitable for industrialization produce of Ginkgo Biloba Softgel.