| 光动力学疗法治疗上消化道癌的临床研究 |
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| 引用本文： | 刘端祺,刘慧龙,介雅慧,徐留柱. 光动力学疗法治疗上消化道癌的临床研究[J]. 中德临床肿瘤学杂志, 2006, 5(2): 90-92. DOI: 10.1007/s10330-006-0464-3 |
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| 作者姓名： | 刘端祺 刘慧龙 介雅慧 徐留柱 |
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| 作者单位： | Department of Oncology, General Hospital of Beijing Military Command, Beijing 100700, China |
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| 摘 要： | Objective： To evaluate the clinical effectiveness and adverse effects of photodynamic therapy （PDT） for the upper gastrointestinal tract cancers. Methods： 56 patients with upper gastrointestinal cancers in different clinical stages were treated with PDT. Diode laser （630 nm） was used as the light source and the parameters were as follows： power density 200 to 400 mW/cm, energy density 100 to 300 J/cm. PHOTOFRIN was used as photosensitizer, which was given in a dose of 2 mg/kg intravenously 12-24 h before irradiation. Results： Evaluation of the 56 patients＇ therapeutic effectiveness showed that 6 patients （10.7%） had a complete response （CR）, 33 patients （58.9%） partial response （PR）, 12 patients （21.4%） mild response （MR）, and 5 patients （8.9%） no response （NR）. The total response rate （CR＋PR） was 69.6%. No patients had severe adverse effects in this group. Conclusion： PDT is an effective and safe palliative modality for upper gastrointestinal tract cancers.
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| 关 键 词： | 激光 光动力学疗法 上消化道癌 |
| 收稿时间： | 2006-02-20 |
| 修稿时间： | 2006-03-20 |
Clinical Study of Photodynamic Therapy for UpperGastrointestinal Tract Cancers |
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| Duanqi LIU,Huilong LIU,Yahui JIE,Liuzhu XU. Clinical Study of Photodynamic Therapy for UpperGastrointestinal Tract Cancers[J]. The Chinese-German Journal of Clinical Oncology, 2006, 5(2): 90-92. DOI: 10.1007/s10330-006-0464-3 |
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| Authors: | Duanqi LIU Huilong LIU Yahui JIE Liuzhu XU |
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| Affiliation: | (1) Department of Oncology, General Hospital of Beijing Military Command, 100700 Beijing, China |
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| Abstract: | Objective: To evaluate the clinical effectiveness and adverse effects of photodynamic therapy (PDT) for the upper gastrointestinal tract cancers. Methods: 56 patients with upper gastrointestinal cancers in different clinical stages were treated with PDT. Diode laser (630 nm) was used as the light source and the parameters were as follows: power density 200 to 400 mW/cm, energy density 100 to 300 J/cm. PHOTOFRIN was used as photosensitizer, which was given in a dose of 2 mg/kg intravenously 12-24 h before irradiation. Results: Evaluation of the 56 patients' therapeutic effectiveness showed that 6 patients (10.7%) had a complete response (CR), 33 patients (58.9%) partial response (PR), 12 patients (21.4%) mild response (MR), and 5 patients (8.9%) no response (NR). The total response rate (CR+PR) was 69.6%. No patients had severe adverse effects in this group. Conclusion: PDT is an effective and safe palliative modality for upper gastrointestinal tract cancers. |
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| Keywords: | photodynamic therapy upper gastrointestinal cancer |
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