| cyclinD1和p27蛋白在膀胱移行细胞癌中的表述 |
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| 引用本文： | 周健,瞿平,唐杏.cyclinD1和p27蛋白在膀胱移行细胞癌中的表述[J].河北医学,2003,9(9):816-818. |
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| 作者姓名： | 周健 瞿平 唐杏 |
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| 作者单位： | 江苏省盐城市第一人民医院泌尿外科,江苏,盐城,224001 |
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| 摘 要： | 目的：探讨膀胱移行细胞癌中cyclinD1和p27蛋白的表达及其意义。方法：采用免疫组化技术检测48例膀胱癌组织中cyclinD1与p27蛋白的表达。结果：cyclinD1及p27表达在膀胱移行细胞癌和正常组织之间各有统计学差异，cyclinD1和p27与膀胱肿瘤分期、分级相关。cyclinD1与p27蛋白呈反方向表达。结论：cydinD1与p27有助于评估膀胱移行细胞癌的生物学行为。
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| 关 键 词： | cyclinD1 p27蛋白 膀胱肿瘤 免疫组织化学 |
The expression of cyclinD1 and p27 in transitional cell carcinoma of bladder |
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| ZHOU Jian,QU Ping,TANG Xing.The expression of cyclinD1 and p27 in transitional cell carcinoma of bladder[J].Hebei Medicine,2003,9(9):816-818. |
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| Authors: | ZHOU Jian QU Ping TANG Xing |
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| Abstract: | Objective: To investigate the expression and significance of cyclinD1 and p27 in transitional cell carcinoma(TCC). Methods: cyclind1 and p27 expression were examined by immunohistochemical technique in 48 case of TCC. Results: The expression of cyclinD1 and p27 protein was significantly different between TCC and normal tissues. The expression rate of cyclinD1 and p27 was correlating with TCC stage. There was a highly significant in verse correlation between the expression of cyclinD1 and p27.Conclusions: CyclinD1 and p27 can evaluate the biological behaviour of TCC. |
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| Keywords: | CyclinD1 p27 protein Bladder neoplasm Immunohischemistry |
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