Cocaine enhances memory storage in mice |
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Authors: | Ines B Introini-Collison James L McGaugh |
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Institution: | (1) Center for the Neurobiology of Learning and Memory, University of California, 92717 Irvine, CA, USA;(2) Department of Pychobiology, University of California, 92717 Irvine, CA, USA |
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Abstract: | Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03–1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage. |
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Keywords: | Cocaine Memory State-dependency Cocaine and reward Catecholamines |
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