Confirmation and further regional assignment of aminoacylase 1 (ACY-1) on human chromosome 3 using a simplified detection method |
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| Authors: | R. VOSS,I. LERER,S. POVEY&dagger ,E. SOLOMON&dagger ,M. BOBROW§ |
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| Affiliation: | *Hadassah University Hospital, Jerusalem;†MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London;†Imperial Cancer Research Fund, Lincoln's Inn Fields, London;§Genetics Laboratory, Department of Biochemistry, Oxford |
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| Abstract: | An improved method for the detection of aminoacylase-1 (ACY-1) is described. Data from human-rodent interspecific hybrids confirm the assignment of ACY-1 to human chromosome 3. The most likely site for ACY-1 appears to be 3p21 to 3pter. The enzyme ACY-1 hydrolyses both acetyl methionine and acetyl glutamate. |
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